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Lux Capital

A podcast by venture capital firm Lux Capital on the opportunities and risks of science, technology, finance and the human condition. Hosted... more

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Evolved Technology: Why technology is counter-intuitively pushing us back to natural products in pharma development

The history of pharmaceutical development has traditionally been one of exploration on the frontiers of life on Earth. From fungi... more

24 Jul 2024 · 21 minutes
The Orthogonal Bet: What the Microsoft Outage Reveals

Welcome to the ongoing mini-series The Orthogonal Bet. Hosted by ⁠Samuel Arbesman⁠, a Complexity Scientist, Author, and Scientist in Residence... more

19 Jul 2024 · 10 minutes
The Orthogonal Bet: The Quest to Find the Poetic Web

Welcome to the ongoing mini-series The Orthogonal Bet. Hosted by Samuel Arbesman, a Complexity Scientist, Author, and Scientist in Residence... more

19 Jul 2024 · 33 minutes
Pivoting to the Expert Economy

The media world has been rocked by artificial intelligence, labor strife, the creator economy, the decimation of business models and... more

17 Jul 2024 · 25 minutes
The Orthogonal Bet: What AI Can Learn from Human Cognition

Hello and welcome to the ongoing miniseries The Orthogonal Bet Hosted by Samuel Arbesman, Complexity Scientist, Author, and Scientist in Residence... more

12 Jul 2024 · 35 minutes
Can we be optimistic about America’s future?

If we had to rebuild American politics to be more positive, could we do it? And what would a positive... more

10 Jul 2024 · 41 minutes
The Orthogonal Bet: Unveiling the Complexity of Life: A Conversation with Philip Ball on ‘How Life Works'

Welcome to The Orthogonal Bet, an ongoing mini-series that explores the unconventional ideas and delightful patterns that shape our world. Hosted... more

05 Jul 2024 · 44 minutes
“The commons are under attack” from TikTok and subsea cables to data centers and elections

2024 is the year of democracy, with more than half of the world’s population voting in elections across India and... more

03 Jul 2024 · 38 minutes
The Orthogonal Bet: How to fund R&D that is for the public good?

In this episode, Sam speaks with Ben Reinhardt, an engineer, scientist, and the founder of a new research organization called... more

28 Jun 2024 · 26 minutes
Is AI killing journalism? Pitchforks, Perplexity and reporters yelling “Boo!”

Another week, another media tempest in a shrinking tea cup. This time, the internet’s ire centered on Perplexity AI, a... more

25 Jun 2024 · 28 minutes
The Orthogonal Bet: SimCity, Maxis and the ambitious modeling of everything

The Orthogonal Bet is an ongoing miniseries of the Riskgaming podcast that explores the unconventional ideas and delightful patterns that... more

21 Jun 2024 · 22 minutes
Why high-throughput bio research needs better tools immediately

There have been data revolutions in most areas of human activity, and biological research is no exception. The rapidly shrinking... more

14 Jun 2024 · 23 minutes
The Orthogonal Bet: Novelist Robin Sloan’s Love for Books with Maps on the First Page

Hello, and welcome to the ongoing mini-series, The Orthogonal Bet, a show that explores the unconventional ideas and delightful patterns... more

07 Jun 2024 · 42 minutes
How Applied Intuition used the Valley’s hardest lessons to upgrade automotive with autonomy

Qasar Younis and Peter Ludwig built Applied Intuition differently from most other startups. At a time of profligate spending at... more

31 May 2024 · 55 minutes
Orthogonal Bet: A technology vibe shift from utopian Star Trek to absurdist Douglas Adams?

This is the inaugural episode of an on-going mini-series for the Riskgaming podcast we’re dubbing the Orthogonal Bet. Organized by... more

24 May 2024 · 28 minutes
The soon-to-be-solved protein problem that will accelerate drug discovery

We’ve known for decades that one of the key mechanisms of biology — and of life itself — is the... more

17 May 2024 · 20 minutes
Margaret Mead and the psychedelic community that theorized AI

How does science progress? One way to look at the question is to peer into individual fields and observe the... more

03 May 2024 · 34 minutes
The nightmare specter of designer bioweapons and the people trying to stop them

Ever since the invention of CRISPR technology about a decade ago, biologists have gained increasing power to discover new DNA... more

26 Apr 2024 · 33 minutes
Lux and the Art of Startup Maintenance

Every quarter, Lux publishes our latest quarterly letter to our limited partners, highlighting the key themes we’re working on as... more

16 Apr 2024 · 24 minutes
The Zone of Totality with Sam Arbesman

This week’s solar eclipse captured the imaginations of millions of Americans throughout an arc across the continent. One of those... more

12 Apr 2024 · 9 minutes
Biology is becoming engineering and not just science

During a recent interview, Nvidia CEO Jensen Huang emphasized his interest in how Nvidia’s AI processing chips could transform the... more

15 Mar 2024 · 24 minutes
The three revolutions in astrobiology and the search for extraterrestrial life

Astrobiology has seen a series of revolutions over the past three decades that have completely reinvigorated the field. Scientists who... more

07 Mar 2024 · 32 minutes
“I am basically a cosmic Fluke” and the chaos of science, policy, and human narratives

Humans are enamored by a good story. The world overloads our mammalian senses, and so we seek any simplifying structure... more

21 Feb 2024 · 33 minutes
How an anonymous blog during the neural network winter led to Japan’s national AI champion

Connections are the key ingredient for careers, society and AI neural networks to boot. Sometimes those connections arise spontaneously and... more

14 Feb 2024 · 45 minutes
The most wasteful infrastructure megaproject that wasn’t

The construction of Boston’s Big Dig highway tunnels has gone down in history as one of the most infamously delayed... more

08 Feb 2024 · 36 minutes
The stove hasn’t changed in decades. It’s time to upgrade.

Home appliances are some of our most used and time-saving technologies, but they have barely evolved since their invention. A... more

02 Feb 2024 · 28 minutes
Astronauts all lie, but the biggest lie is that we will colonize Mars (Zach Weinersmith, Part 1 of 2)

Colonizing Mars has gone from the speculative fiction section of the bookstore right into the halls of Congress. Entrepreneurs led... more

24 Jan 2024 · 26 minutes
Why a Mars settlement could never be a libertarian paradise (Zach Weinersmith, Part 2 of 2)

The current drive for a Mars colony revolves around two central axes: one is a fear of existential risk and... more

24 Jan 2024 · 25 minutes
How Impulse Space’s Helios will democratize access to Earth’s farthest orbits

The cost of launching a payload into low-earth orbit has shrunk dramatically over the past two decades as SpaceX has... more

17 Jan 2024 · 15 minutes
Why Tokyo’s Sakana AI is pioneering a new vanguard of national AI foundation models

Lux announced big news today: we are leading a $30 million founding seed round into Sakana AI, a Tokyo, Japan-based... more

16 Jan 2024 · 9 minutes
WTF Happened in AI in 2023?

Hey, it's Danny Crichton. 2023 was an incredibly busy year, and nowhere was there more fervent attention than on artificial... more

21 Dec 2023 · 44 minutes
Eliot Peper's new novel 'Foundry' and the Future

In a world where science fiction often paints a pessimistic picture of dystopian futures and critiques of modern technology, novelist... more

15 Dec 2023 · 40 minutes
Erik Hoel (part 2): Dreaming, AI, and the Future of Education

Ever wonder if your dreams were more than just dreams? Dive into an intriguing conversation with Erik Hoel on our... more

13 Dec 2023 · 24 minutes
Erik Hoel (part 1): The Consciousness Winter

In this episode of the "Securities" podcast, host Danny Crichton leads a discussion on consciousness with guests Erik Hoel, Josh... more

08 Dec 2023 · 35 minutes
Techno-Pragmatism: Looking Beyond Blind Optimism and Hopeless Pessimism

Welcome to "Securities," a podcast and newsletter about science, technology, finance, and the human condition. In this episode, Danny Crichton... more

01 Dec 2023 · 31 minutes
AI: Disruption, Regulation, and the Road Ahead

In this episode of “Securities” by Lux Capital, host Danny Crichton joins guests Brian McCullough, host of the Techmeme Ride... more

17 Nov 2023 · 35 minutes
Navigating the Crossroads: Technology, Democracy, and National Security with Miles Taylor

Welcome to this enlightening episode of "Securities” Podcast with host Danny Crichton, where we navigate the intricate crossroads of technology,... more

15 Sep 2023 · 47 minutes
Lt. Gen. Jack Shanahan on rebuilding trust between Silicon Valley and the Pentagon

As the birthplace of semiconductors and computers, Silicon Valley has historically been a major center of the defense industry. That... more

30 Aug 2023 · 42 minutes
Simulating Evolution: Playing God or the Next Frontier?

Artificial life, aka “A-life”, is an intellectually vital field simulating life within computational systems. By allowing simulations to run uninterrupted... more

18 Aug 2023 · 44 minutes
How many creators will survive generative AI?

Think AI can't touch the creative world? Think again. Writers, directors, illustrators - none are safe. AI models, despite their... more

15 Aug 2023 · 5 minutes
We need to go deeper with the inception of deep geothermal energy

Historians survey the past and the Twitterati (X-erati?) process the events of the present day. But what does it mean... more

04 Aug 2023 · 35 minutes
The Science of Survival: Adapting Human Life for Other Planets

Welcome to "Securities," a podcast and newsletter devoted to science, technology, finance, and the human condition. In this episode, Josh... more

28 Jul 2023 · 38 minutes
The p-zombie theory of consciousness

The rise of generative AI and large-language models (LLMs) have forced computer scientists and philosophers to ask a fundamental question:... more

14 Jul 2023 · 41 minutes
Fertility Rules from wildfire sperm death and microplastics to the potential of AI w/ Leslie Schrock

The birds and the bees just don’t cut it anymore. With the rising age of first pregnancies in America, optimizing... more

07 Jul 2023 · 30 minutes
“There are more astronauts alive than there are perfumers”: the complex supply chains of scents

While the natural world is fecund with a dazzling diversity of smells, the landscape of scents in our daily lives... more

11 Apr 2023 · 17 minutes
“It subverts the structure even of other stories that are told about creation”

In a quantified world, the act of creation remains mysterious. Where do ideas come from? How does an artist translate... more

04 Apr 2023 · 27 minutes
“Smell can be art, and it also can be science”: AI/ML and digital olfaction

We perceive the world through our senses, watching the sunset, hearing the staccato of a violin soloist, smelling and ultimately... more

29 Mar 2023 · 26 minutes
How exponentials on top of exponentials in single-cell analysis is transforming biology today

It’s been a long road to mastering the cell, but biological scientists think they are getting closer and closer to... more

21 Mar 2023 · 21 minutes
First impressions of OpenAI’s new GPT-4 AI model

ChatGPT has overtaken the cultural zeitgeist faster than any consumer service in the history of technology, with some analysts estimating... more

15 Mar 2023 · 14 minutes
Chatphishing, veracity and “two years of chaos and a reset”

The Lux LP quarterly letter has become an institution for its intricate weave of pragmatic cynicism about human nature and... more

14 Mar 2023 · 36 minutes
May the AI be ever in your favor

While much of the venture world has hit a reset in 2023, you’d never know that in artificial intelligence, where... more

03 Mar 2023 · 23 minutes
“That’s 100% what keeps me up at night”: Gary Marcus on AI and ChatGPT

Artificial intelligence has become ambient in our daily lives, scooting us from place to place with turn-by-turn navigation, assisting us... more

10 Feb 2023 · 23 minutes
Why quitters are heroes with “Quit” author Annie Duke

They say that you miss 100% of the shots you don’t take, but what if each shot costs money and... more

27 Jan 2023 · 29 minutes
“I have three girls; the second one is bionic”

Technology’s prime and still growing role in society has led to a crescendo of criticism that it has exacerbated inequality.... more

20 Oct 2022 · 14 minutes
We will observe a battle for the true openness in AI

No technology has as many dual-use challenges as artificial intelligence. The same AI models that invent vivacious illustrations and visual... more

12 Oct 2022 · 23 minutes
There’s always been a global race to develop chip technology

Semiconductors are ubiquitous in modern life, powering our appliances, smartphones, cars and electronics. That’s led to soaring demand from consumers,... more

05 Oct 2022 · 28 minutes
Perhaps our greatest achievement is not being present

We live in a time of tremendous focus on … focus and productivity. Scan the shelves of any self-help section... more

30 Sep 2022 · 24 minutes
Web3 is so far behind in terms of reliability and security

Episode reading list: The future of crypto regulation: Highlights from the Brookings event Lux + Tactic funding announcement Fourteen years after the release... more

27 Sep 2022 · 17 minutes
How to recapitalize America’s bloated defense industrial base

Episode reading list:  Forging the Industrial Network the Nation Needs Defense Fordism and AI Rebooting the Arsenal of Democracy The Return of Industrial Warfare America... more

21 Sep 2022 · 23 minutes
The utopian visions of Stanford’s generations of entrepreneurs

Stanford University is at the beating heart of Silicon Valley and has become almost a rite of passage for generations... more

16 Sep 2022 · 23 minutes
The geopolitics and digital future of agricultural commodities

Agricultural commodities is a bit like accounting: you only hear news stories about it when things go wrong. And unfortunately... more

10 Sep 2022 · 22 minutes
Reputations are always a trailing indicator of truth

“Securities” podcast host Danny Crichton and producer Chris Gates talk about the latest newsletter issue, “Truth and reputations.” Reputations are... more

23 Aug 2022 · 17 minutes
Crypto and incentive design with MIT Cryptoeconomics Lab’s Christian Catalini

Humans have been bartering and trading for millennia, building extraordinarily complex mechanisms of exchange centered on fiat currencies, contracts, and... more

17 Aug 2022 · 25 minutes
VC 101: the denominator effect

Recently in the Lux Capital office, my colleague Chris Gates, the producer of the "Securities” podcast, along with biotech investor... more

03 Aug 2022 · 16 minutes
How new communities are propelling the future of tech + bio

There has been a massive expansion in data emanating from bio labs, and that means next-generation AI algorithms and machine... more

01 Aug 2022 · 21 minutes
Maybe the world is effing amazing and I am just reading the wrong things

“Securities” podcast host Danny Crichton and producer Chris Gates talk about the last two weeks of “Securities” newsletters. The first,... more

25 Jul 2022 · 21 minutes
How health tech startups are responding to the post-Roe world?

Welcome to “Securities” by Lux Capital, a podcast and newsletter devoted to science, technology, finance and the human condition. I'm... more

23 Jul 2022 · 28 minutes
The United States has never won a conflict with the hardware that it had going into it

Today we're talking about the future of American defense. And we have three of the leaders changing the trajectory of... more

15 Jul 2022 · 24 minutes
How will AI art generators affect human creativity?

Here is my dilemma, I want custom art for the podcast. Ideally, I would have a new image for each... more

09 Jul 2022 · 13 minutes
Shoving the rocket into space with your bare hands

SpaceX has grown from nascent dreams of the final frontier into the world’s premier commercial space launch company, with dozens... more

02 Jul 2022 · 20 minutes
Vaporware skepticism

"Where marginal stupidity is about  “how there is a turning point where further information or complexity can befuddle us and... more

25 Jun 2022 · 20 minutes
Lazy tech analogies

"The world is incredibly complicated, and humans necessarily use heuristics and analogies to process that complexity into simpler forms. These... more

18 Jun 2022 · 22 minutes
Alternate Histories and GPT-3

"GPT-3 was trained on is so large that the model contains a certain  fraction of the actual complexity of the... more

17 Jun 2022 · 16 minutes
Marginal Stupidity

"One of the most important cognitive tradeoffs we make is how to process information, and perhaps more specifically, the deluge... more

14 Jun 2022 · 12 minutes
The ESG Mirage

"The activities of an extremely complicated phenomenon like a  multi-national corporation cannot be reduced to five-star ratings,  particularly on a... more

11 Jun 2022 · 6 minutes
Jonathan Haidt on American structural stupidity and the post-Babel world (Part 1)

Speech and the right to it has become deeply contested across America in the 21st Century. What is free speech,... more

04 Jun 2022 · 18 minutes
Jonathan Haidt on how tech can change social media and save democracy (Part 2)

In part one of this interview, Jonathan Haidt described his recent article in The Atlantic on America’s structural stupidity and... more

04 Jun 2022 · 26 minutes
Speculative fiction is a prism to understand people

Speculative fiction is a long-running but increasingly popular genre of science fiction that uses a variety of imaginative techniques to... more

26 May 2022 · 29 minutes
Will Malthus or human ingenuity win out in these chaotic times?

It’s been another crazy week of financial news, but how do all these trends add up? This week, Danny Crichton... more

21 May 2022 · 29 minutes
If you’re not solving for pain, then what the hell are you doing?

Tony Fadell is the consummate Silicon Valley builder, having conceived, designed and executed such iconic products as the Apple iPod... more

17 May 2022 · 30 minutes
Risk, Bias and Decision Making: Pre-mortems

Recently at Lux in New York City, Josh Wolfe invited three celebrated decision and risk specialists for a lunch to... more

14 May 2022 · 18 minutes
Risk, Bias and Decision Making: People never change their minds

Recently at Lux in New York City, Josh Wolfe invited three celebrated decision and risk specialists for a lunch to... more

14 May 2022 · 9 minutes
Risk, Bias and Decision Making: Defying the odds

Recently at Lux in New York City, Josh Wolfe invited three celebrated decision and risk specialists for a lunch to... more

14 May 2022 · 21 minutes
Risk, Bias and Decision Making: Hot hands

Recently at Lux in New York City, Josh Wolfe invited three celebrated decision and risk specialists for a lunch to... more

14 May 2022 · 6 minutes
Shredding the endowment investing playbook w/Scott Wilson, CIO of Washington University in St. Louis

University endowments are one of the key nexuses by which finance influences the future of science, tech, and the human... more

07 May 2022 · 34 minutes
The future of biotech is moving from bench to beach

While a huge amount of attention is being directed at crypto and media these days, one of the most important... more

30 Apr 2022 · 15 minutes
Chip demand and the future of the climate with Mythic AI’s Mike Henry

There’s a huge expansion in demand for compute power going on, with AI models, cryptocurrencies, autonomous vehicles and our social... more

23 Apr 2022 · 17 minutes
Redlines for diplomacy and business with former USSOCOM commander Tony “T2” Thomas

“Redlines” in war are meant to be objective and unambiguous tests for a country to respond to another nation’s action.... more

16 Apr 2022 · 14 minutes
The VC Power Law with CFR senior fellow Sebastian Mallaby

In his new book, “The Power Law: Venture Capital and the Making of the Future,” Council on Foreign Relations senior... more

09 Apr 2022 · 26 minutes
Is web3 really just looking for Web 2.5?

web3 technologies have received prodigious funding the past two years as founders and VCs collectively search for the path to... more

05 Apr 2022 · 12 minutes
Josh Wolfe on “There will be chaos, and that chaos will be caused by people”

Josh Wolfe and Danny Crichton talk about the influx of TV shows covering startup busts including WeCrashed, Super Pumped, and... more

02 Apr 2022 · 18 minutes
Rethinking the science of science funding with Sam Arbesman

The funding of science is one of the most important leverage points for growth in the global economy. Yet, we’ve... more

31 Mar 2022 · 16 minutes
Episode 01: Silicon Valley’s dependence on American foreign policy

Danny Crichton talks with TechCrunch Global Affairs Project special series editor Scott Bade about the passing of Madeleine Albright, the... more

25 Mar 2022 · 29 minutes
Episode 0: A Pod is Born, Alife is Funded, and A Decade is Defined

In Episode 0 of “Securities” by Lux Capital, Danny Crichton and Chris Gates talk about why the world needs another... more

22 Mar 2022 · 14 minutes
Episode 0: A Pod is Born, Alife is Funded, and A Decade is Defined

Listen now on

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In Episode 0 of “Securities” by Lux Capital, Danny Crichton and Chris Gates talk about why the world needs another podcast; Deena... more