Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Player FM - Internet Radio Done Right
48 subscribers
Checked 6d ago
Added six years ago
Content provided by Joel Topf and NephJC Team. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Joel Topf and NephJC Team or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Similar to Freely Filtered, a NephJC Podcast
Emergency Medicine Cases – Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
…
continue reading
Come dive into one of the curiously delightful conversations overheard at National Geographic’s headquarters, as we follow explorers, photographers, and scientists to the edges of our big, weird, beautiful world. Hosted by Peter Gwin and Amy Briggs.
…
continue reading
The BMJ brings you interviews with the people who are shaping medicine and science around the world.
…
continue reading
Help me fill in the blanks of the practice of ED Critical Care. In this podcast, we discuss all things related to the crashing, critically ill patient in the Emergency Department. Find the show notes at emcrit.org.
…
continue reading
Science Friction has a new series: Cooked. We dig into food science pickles. Why are studies showing that ice cream could be good for you? Do we really need as many electrolytes as the internet says? And why are people feeling good on the carnivore diet? Nutrition and food scientist Dr Emma Beckett takes us through what the evidence says about food categories and ingredients like meat, dairy and salt — and unpick why nutrition studies can be so conflicting and confusing. Airs Wednesday 11:30 ...
…
continue reading
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
…
continue reading
How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
…
continue reading
Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
…
continue reading
We humans could have a bright future ahead of us that lasts billions of years. But we have to survive the next 200 years first. Join Josh Clark of Stuff You Should Know for a 10-episode deep dive that explores the future of humanity and finds dangers we have never encountered before lurking just ahead. And if we humans are alone in the universe, if we don't survive intelligent life dies out with us too.
…
continue reading
Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
))
Daily Deals
Podcasts Worth a Listen
SPONSORED
R
Rethinking Alzheimer's Disease Podcast
Learn about the differences between Alzheimer's and dementia, and how Alzheimer's disease progresses. We talk about why catching the disease early can make a big difference. Dr. Sharon Cohen and Dr. Yaakov Stern walk us through the stages of Alzheimer's disease, from when there are no symptoms to when memory issues start to show. They explain the stages of Alzheimer’s and how it develops over time. We also hear from Kelly, who explains her personal experiences and concerns about developing Alzheimer’s, and what she does about it. For links to resources and information covered in this series, visit our website at HealthUnmuted.com/resources What did you think of this episode? We’d love to hear from you. Please visit healthunmuted.com/feedback to let us know! Rethinking Alzheimer’s Disease was made possible with support from Eisai Inc. [00:00:00] Introduction [00:03:10] What's the difference between Alzheimer's disease and dementia? [00:07:04] When does Alzheimer’s begin to develop? [00:09:08] What is Mild Cognitive Impairment (MCI)? [00:10:36] What is subjective cognitive decline? [00:11:59] What is preclinical Alzheimer's disease? [00:13:13] Why is it important to detect Alzheimer’s disease early? Disclaimer: The content provided in this podcast is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on this podcast. Reliance on any information provided by this podcast or its guests is solely at your own risk. ©2024 Mission Based Media Ltd • April 2024 • AD-M2059…
Freely Filtered, a NephJC Podcast
Mark all (un)played …
Manage series 2540759
Content provided by Joel Topf and NephJC Team. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Joel Topf and NephJC Team or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.
79 episodes
Share
Mark all (un)played …
Manage series 2540759
Content provided by Joel Topf and NephJC Team. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Joel Topf and NephJC Team or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://player.fm/legal.
Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.
79 episodes
All episodes
×
F
Freely Filtered, a NephJC Podcast
1 FF 78 NephMadness, the dialysis region 1:08:59
1:08:59 
Play Later 
Play Later 
Lists 
Like 
Liked1:08:59
Play Later Play Later Lists Like LikedThe Filtrate Joel Topf Jordy Cohen Nayan Arora Special Guest Katie Kwon @katiekwonmd.bsky.social Mariana Murea @MarianaMurea Editing by Simon Topf and Joel Topf Show Notes NephMadness at AJKDblog.org The Hemodialysis Region Vot e for your favorites
F
Freely Filtered, a NephJC Podcast
The Filtrate Joel Topf Swapnil Hiremath AC Gomez Sopia Ambruso Nayan Arora Special Guests Michelle Rheault , Director, Division of Pediatric Nephrology, Professor of Medicine Tiffany Caza , Nephropathologist, Scientist and self-described Freely Filtered fan girl Editing by Simon Topf and Sophia Ambruso Show Notes 10. Healthcare Cyberattacks 9. ApoE in C3 glomerulonephropathy 8. Workforce woes in Adult and Pediatric Nephrology 7. Hyponatremia correction meta-analysis 6. Microvascular inflammation increases risk of graft loss - in all of its forms 5. Xenotransplantation 4. KDIGO CKD Guidelines 3. Hypertension control trials (ESPRIT, BPROAD) 2. The Renaissance of IgAN: IgAN treatment trials 1. FLOW: GLP-1 RAs in CKD…
F
Freely Filtered, a NephJC Podcast
The Filtrate Joel Topf Swapnil Hiremath AC Gomez Jordy Cohen Nayan Arora Special Guest Brendon Nuen Editing by Simon Topf and Nayan Arora Show Notes FINEARTS-HF in NEJM FINEARTS Kidney outcomes in JACC FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes in Nature Medicine discussion in NephJC BARACH-D: Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial ( Nature Medicine ) Live Freely Filtered at KidneyWk Swapnil comes out as a SpiroStan post to NephJC TOPCAT TOPCAT primary publication TOPCAT North American results TOPCAT funny business explained AHA/ACC/HFSA Heart Failure Guidelines ( PDF ) SGLT2i are 2a MRA are a 2b ARBs are a 2b ARNI are a 2b Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction: Detailed Phenotypes, Prognosis, and Response to Spironolactone Kansas city cardiomyopathy questionnaire in patients with CKD without a diagnosis of heart failure: https://pubmed.ncbi.nlm.nih.gov/21187260/ GFR slope with steroidal MRAs in HF: https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2635 Why Has it Been Challenging to Modify Kidney Disease Progression in Patients With Heart Failure? ( JACC ) Tubular Secretions Swap: Disclaimer on Apple TV AC: Duo Lingo Plushy ( Amazon ) Nayan: The Puzzle Box Jordy: Project Hail Mary Brendon has a podcast, The Kidney Compass with Shikha Wadhwani. And he recommends singer-songwriter, Maggie Rogers ( YouTube ) Joel: The Singularity Is Nearer: When We Merge with AI by Ray Kurzweil Closing music, Tim Yau with The Kidney Connection…
F
Freely Filtered, a NephJC Podcast
1 Episode 70b Do Over: Predicting Preeclampsia, the PRAECIS trial 34:50
34:50 Play Later Play Later Lists Like Liked34:50
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath With Special Guest: Michelle Hladunewich , Nephrologist at the University of Toronto Mir Melamed , Maternal-Fetal Medicine at the University of Toronto Editor Simon Topf Show Notes Priscilla Smith’s letter: Dear Joel and the Freely Filtered team, I am a long-time fan of your podcast and was looking forward to hearing your recently aired discussion of the Praecis study of sflt1:PlGF use in preeclampsia. Preeclampsia and renal disease in pregnancy are areas that many nephrologists report a lack of knowledge or confidence in discussing and managing. I am a nephrologist who has been co-leading a renal pregnancy clinic in London while writing a PhD on progression of renal disease in pregnancy. I have had the immense privilege of working with experts and key opinion leaders in preeclampsia research both in the UK and internationally. As you know, preeclampsia is a serious and significant condition contributing to global maternal mortality and is also associated with future CKD and CVD risk so is both relevant and important within our professional group. Sadly, I found myself disappointed by the episode and felt it was a missed opportunity. I appreciate that you had difficulties obtaining appropriate experts to join the discussion, but perhaps it would have been better to delay production. While you all valiantly proceeded to discuss this important study, the topic is complex and there appeared to be a lack of understanding of the surrounding literature and pathogenesis of preeclampsia. Sadly, the maternal medicine expert’s comments at the end of the podcast added little as she seemed determine to negate any benefit from the results despite declaring she had no experience or expertise in the use of these biomarkers. There are many people who understand the clinical aspects of preeclampsia as well as having direct experience of the use and utility of these biomarkers who would have been able to contribute much to your conversation. I look forward to future discussions of renal disease in pregnancy on your podcast and would be happy to suggest some expert panellists if you ever find yourself stuck. Kind regards, Priscilla Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia ( JCI 2003 ) sFlt background: Pathogenesis of Preeclampsia and Therapeutic Approaches Targeting the Placenta ( PubMed ) PlGF background: Perspectives on the Use of Placental Growth Factor (PlGF) in the Prediction and Diagnosis of Pre-Eclampsia: Recent Insights and Future Steps ( PubMed ) The PRAECIS trial ( NephJC | NEJM Evidence )…
F
Freely Filtered, a NephJC Podcast
We had a great NephJC get together. We recorded the whole event and packaged it into a podcast. Musical entertainment Tim Yau ( @Maximal_Change ) Too Sweet by Hozier Fairy Tale of New York by written Jem Finer and Shane MacGowan . Hear it performed by the Pogues . Interview of Tom Mueller Tom Mueller author of How to Make a Killing Jade Teakall @jmteakell Graham Abra @GrahamAbra Interview of Tom Mueller Tom Mueller author of How to Make a Killing Jade Teakall @jmteakell Graham Abra @GrahamAbra NephMadness logo reveal NephJC Kidneys NephJC blog post NephJC Manuscript of the Year : Flow accepted by Meg Jardine Manjula Kurella Tamura, winner of the 2015 NephMadness , oh and author of NEJM manuscripts and subject of a NYT article . NephJC Visual Abstract of the Year : Corina Teodusiu, creator of the Flozinator logo NephJC Social Justice Award : ISN petition to the WHO on Kidney Health Most Engaged Scientist Award : Michelle Rheault Rookie of the Year : Milagros Flores MVP : Christina Popa NephJC Founders Award : Joshua Waitzman Nathan Hellman Social Media Project of the Year : Edgar Lerma and the ASN Visual Abstract Team More Music with Tim Saginaw, Michigan as performed by Johny Cash Betty, written by Taylor Swift The Kidney Connection Freely Filtered Kidney Week Draft Previous drafts 2021 ASN Kidney Week Draft 2022 ASN Kidney Week Draft 2023 ASN Kidney Week Draft List of all the simultaneous publications from Kidney Week 2024 Sophia : SMART Trial (Link goes to the new KidneyCompass podcast that interview lead author Hiddo Heerspink Jordy’s editorial in the European Heart Journal. Link Josh : APPLAUSE Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy in the NEJM APPLAUSE results announcement at The World Congress of Neophrology in Buenos Aries Iptapocan is a factor B inhibition Jordy : POISE-3 with simultaneous publication in KI Mentions she wanted to pick KAT-AKI because she worked with Perry Wilson. Per Nayan, Amit Garg is the Beyonce of Nephrology Accord Trial ( NEJM ) Joel : HSK21541 for Pruritus Correction link to source (graph) Nayan : FINEARTS-HF with simultaneous publication in JACC BARACH-D: Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial (Nature Medicine) Swapnil comes out as a SpiroStan TOPCAT funny business PATHWAY-2 Trial ( NephJC coverage ) Swap : K Bath and cardiac arrhythmia with simultaneous publication in Kidney International CAST: A study that rocked the cardiology world and became the poster child for evidence-based medicine ( Link ) Tubular Secretions Swap: Late breaking and high impact sessions Nayan: Intro to… Joel: Student poster on blood pressure technique Jordy: The Penguin. A couple of mentee posters Sophie: Tracks her sessions on paper. Josh: Quiz and Questionaire session with JC Velez, Bea Concepcione, Anna Burgner, Roger Rodby.…
F
Freely Filtered, a NephJC Podcast
The Filtrate: Jennie Lin Joel Topf Josh Waitzman Swapnil Hiremath With Special Guests Pedro Teixeira Jay Koyner Editor Sophia Ambruso Show Notes The article: A Randomized Trial of Intravenous Amino Acids for Kidney Protection NephJC Summary KDIGO Clinical Practice Guideline for Acute Kidney Injury ( PDF ) Steve Coca study Evaluation of Short-Term Changes in Serum Creatinine Level as a Meaningful End Point in Randomized Clinical Trials ( PubMed ) Using Nephrocheck to prevent AKI: Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial ( PubMed ) Brenner’s Review of protein intake and renal hemodynamics: Dietary Protein Intake and the Progressive Nature of Kidney Disease: — The Role of Hemodynamically Mediated Glomerular Injury in the Pathogenesis of Progressive Glomerular Sclerosis in Aging, Renal Ablation, and Intrinsic Renal Disease ( NEJM ) Husain-Syed a look at preoperative renal functional reserve and risk of AKI: Preoperative Renal Functional Reserve Predicts Risk of Acute Kidney Injury After Cardiac Operation ( PubMed ) Dana Fuhrman review of renal functional reserve: The Role of Renal Functional Reserve in Predicting Acute Kidney Injury ( PubMed ) Use of SGLT2i prevented AKI in the placebo controlled trials. Clinical Adverse Events Associated with Sodium-Glucose Cotransporter 2 Inhibitors: A Meta-Analysis Involving 10 Randomized Clinical Trials and 71 553 Individuals ( PubMed ) Assessment of P values for demographic data in randomized controlled trials ( PubMed ) Tubular Secretions Swapnil The Lord of the Rings: Rings of Power Season 2 on Amazon Prime ( Wikipedia ) Josh Fortnite ( Website ) Pedro CRRT Academy at University of Alabama Birmingham ( Website ) Jay Koyner Slow Horses on AppleTV ( Wikipedia ) Jennie Linn #KidneyWk Run Club Friday 10/25 at 6:15 am PST Meet in front of Sally’s Fish House ~2 miles. Easy pace (10-12 min/mile) ( Strava ) Joel Topf Your Honor on Netflix ( Wikipedia )…
F
Freely Filtered, a NephJC Podcast
1 Episode 73: The KDIGO CKD 2024 Guideline Draft 1:32:16
1:32:16 Play Later Play Later Lists Like Liked1:32:16
Play Later Play Later Lists Like LikedThe draft order: Sophia Ambruso Nayan Arora Swapnil Hiremath AC Gomez Joel Topf Editor Nayan Arora Show Notes Previous drafts: 2021 KDIGO Hypertension —Joel, Sophia, Swap, Nayan, Josh 2021 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan, Jennie 2022 The ISPD Peritonitis Guideline— Joel, Sophia, Swap, Nayan 2022 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan 2023 ASN Kidney Week Draft—Joel, Sophia, Swap, Nayan, AC, Josh 2024 KDIGO CKD Clinical Practice Guideline —Joel, Sophia, Swap, Nayan, Josh, AC The guideline The NephJC discussion Part 1 | Part 2 First Round Sophia’s Pick 3.7.1 We recommend treating patients with type 2 diabetes (T2D), CKD, and an eGFR ≥20 ml/min per 1.73 m2 with an SGLT2i (1A). Not Nayan’s Pick 3.7.3: We suggest treating adults with eGFR 20 to 45 ml/min per 1.73 m2 with urine ACR <200 mg/g (<20 mg/mmol) with an SGLT2i (2B). Nayan’s Pick 2.2.1: In people with CKD G3–G5, we recommend using an externally validated risk equation to estimate the absolute risk of kidney failure (1A). A birdie told me there will not be a Tangri KFRE vs the World debate at Kidney Week The action points based on absolute risk results: Practice Point 2.2.1: A 5-year kidney failure risk of 3%–5% can be used to determine need for nephrology referral in addition to criteria based on eGFR or urine ACR, and other clinical considerations. Practice Point 2.2.2: A 2-year kidney failure risk of >10% can be used to determine the timing of multidisciplinary care in addition to eGFR-based criteria and other clinical considerations. Practice Point 2.2.3: A 2-year kidney failure risk threshold of >40% can be used to determine the modality education, timing of preparation for kidney replacement therapy (KRT) including vascular access planning or referral for transplantation, in addition to eGFR-based criteria and other clinical considerations. Swap’s Pick 3.15.1.1: In adults aged ‡50 years with eGFR <60 ml/min per 1.73 m2 but not treated with chronic dialysis or kidney transplantation (GFR categories G3a–G5), we recommend treatment with a statin or statin/ezetimibe combination (1A). AC’s Pick 3.7.2: We recommend treating adults with CKD with an SGLT2i for the following (1A): eGFR ≥20 ml/min per 1.73 m2 with urine ACR ≥200 mg/g (≥20 mg/mmol), or heart failure, irrespective of level of albuminuria. (1A) Joel’s Pick 3.10.1: In people with CKD, consider use of pharmacological treatment with or without dietary intervention to prevent development of acidosis with potential clinical implications (e.g., serum bicarbonate <18 mmol/l in adults). Practice Point 3.10.2: Monitor treatment for metabolic acidosis to ensure it does not result in serum bicarbonate concentrations exceeding the upper limit of normal and does not adversely affect BP control, serum potassium, or fluid status. Freely Filtered 061 : Bicarb in Transplant with Nav Tangri Second Round Joel’s Pick 3.3.1.1: We suggest maintaining a protein intake of 0.8 g/kg body weight/d in adults with CKD G3–G5 (2C). Practice points related to protein intake: 3.3.1.1: Avoid high protein intake (>1.3 g/kg body weight/d) in adults with CKD at risk of progression. 3.3.1.2: In adults with CKD who are willing and able, and who are at risk of kidney failure, consider prescribing, under close supervision, a very low–protein diet (0.3–0.4 g/kg body weight/d) supplemented with essential amino acids or ketoacid analogs (up to 0.6 g/kg body weight/d). 3.3.1.3: Do not prescribe low- or very low–protein diets in metabolically unstable people with CKD. AC’s Pick 3.9.1: In adults with T2D and CKD who have not achieved individualized glycemic targets despite use of metformin and SGLT2 inhibitor treatment, or who are unable to use those medications, we recommend a long-acting GLP-1 RA (1B). Swapnil’s Pick Practice Point 5.4.1: Initiate dialysis based on a composite assessment of a person’s symptoms, signs, QoL, preferences, level of GFR, and laboratory abnormalities. IDEAL Trial: A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis NEJM Timing of dialysis initiation to reduce mortality and cardiovascular events in advanced chronic kidney disease: nationwide cohort study NephJC Nayan’s Pick Practice Point 1.1.4.2: Use tests to establish a cause based on resources available (Table 6b). Sophia’s Pick Practice Point 1.1.1.2: Following incidental detection of elevated urinary albumin-to-creatinine ratio (ACR), hematuria, or low estimated GFR (eGFR), repeat tests to confirm presence of CKD. Joel’s cystatin C Tweet The cystatin C guideline recommendation 1.1.2.1: In adults at risk for CKD, we recommend using creatinine-based estimated glomerular filtration rate (eGFRcr). If cystatin C is available, the GFR category should be estimated from the combination of creatinine and cystatin C (creatinine and cystatin C– based estimated glomerular filtration rate [eGFRcr-cys]) (1B). Nayan’s additional thoughts. He is not a fan of Practice Points 3.6.4 and 3.6.5 Practice Point 3.6.4 Continue ACEi or ARB therapy unless serum creatinine rises by more than 30% within 4 weeks following initiation of treatment or an increase in dose. and Practice Point 3.6.5: Consider reducing the dose or discontinuing ACEi or ARB in the setting of either symptomatic hypotension or uncontrolled hyperkalemia despite medical treatment, or to reduce uremic symptoms while treating kidney failure (estimated glomerular filtration rate [eGFR] <15 ml/min per 1.73 m2). Tubular Secretion Swap The Murderbot Diaries by Martha Wells Nayan Searching for Hobey Baker Narrated by David Duchovny AC Rosie Revere, Engineer Sophia Bassnectar How to fix the Apple Music automatically playing when you connect to bluetooth. Joel The Veil with Elizabeth Moss…
F
Freely Filtered, a NephJC Podcast
1 Episode 72: Nefecon for IgAN, The NefIgArd part B trial 1:32:16
1:32:16 Play Later Play Later Lists Like Liked1:32:16
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Josh Waitzman With Special Guest: Brad Rovin ( @BradRovin ) Chief of nephrology at The Ohio State University Wexner Medical Center, one of the authors of the Nefigard trial. Koyal Jain ( @koyaljainMD ) Program director of the GN Fellowship at University of North Carolina Roger Rodby ( @NephRodby ) Associate program director of the Rush University Nephrology Fellowship Editor Sophia Ambruso Show Notes The manuscript ( The Lancet | PubMed | NephJC ) The Results of Part A ( Kidney Int | PubMed ) Edmund (Ed) Louis memorium by Steve Korbet in KI Steve Korbet Do not miss this tweet TESTING Freely Filtered #48 with Sean Barbour Iptapocan at the World Congress of Nephrology: WCN24-1506 Efficacy And Safety Of Iptacopan In Patients With IgA Nephropathy: Interim Results From The Phase 3 APPLAUSE-IgAN Study FDA and mandatory post-marketing studies. What happens when the study is negative (or not completed) ( UNDARK ) Who should treat lupus nephritis: rheumatologists or nephrologists? ( Nature Reviews Nephrology ) Protein and albumin-to-creatinine ratios in random urines accurately predict 24 h protein and albumin loss in patients with kidney disease ( PubMed ) MEST Scores in NephJC Risk scores in IgAN in NephJC Repeat renal biopsy improves the Oxford classification-based prediction of immunoglobulin A nephropathy outcome ( NDT ) Tarpeyo pills 4 mg. Four pills once a day. ( WellRx has a picture of the pills) IgA nephropathy in African Americans: uncommon but possible ( PubMed Central ) Aberrantly Glycosylated IgA1 in IgA Nephropathy: What We Know and What We Don’t Know ( PubMed Central ) Effectiveness of Mycophenolate Mofetil Among Patients With Progressive IgA Nephropathy ( JAMA Network Open ) Tubular Secretions Joel : Constellation on Apple TV ( Wikipedia ). Not good. Dune audio books are excellent. ( Audible ) Josh : Podcasts about donating a kidney One Is Enough Podcast ( National Kidney Registry ) Donor Diaries ( National Kidney Donation Organization ) Roger Iceland ( Wikipedia ) Koyal India ( Wikipedia ) Brad Fishing in Dubai…
F
Freely Filtered, a NephJC Podcast
The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Nayan Arora Sophia Ambruso With Special Guest: Brendon Neuen Super smart guy and clinical trialist Vlado Perkovic Lead author of FLOW and friend of NephJC Editor Joel Topf Show Notes The manuscript ( NEJM ): Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes The acronym FLOW from the title: evaluate renal F unction with semag L utide O nce W eekly ( Twitter ) Joel wrote a blog post prior to the FLOW publication to try to set the table: Peeking Inside Schrödinger’s Box Brendon’s Neuen’s tweet about total versus chronic slope ( X | Twitter ) Modification of Association of Cystatin C With Kidney and Cardiovascular Outcomes by Obesity ( Science Direct ) Semaglutide and Diabetic Retinopathy Risk in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials ( PubMed ) The Efficacy and Safety of the Combination Therapy With GLP-1 Receptor Agonists and SGLT-2 Inhibitors in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis ( Frontiers in Pharmacology ) Statistical considerations for testing multiple endpoints in group sequential or adaptive clinical trials ( PubMed ) Proteinuria Thresholds Are Irrational: A Call for Proteinuria Indexing ( Nephron Clinical Practice ) Frank Harrel on why the NNT sucks ( data methods ) Regulation of Na+/H+ exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells ( PubMed ) Switching Between Glucagon-Like Peptide-1 Receptor Agonists: Rationale and Practical Guidance ( PubMed ) Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial ( PubMed ) Doctors are like the pyromaniac fireman ( PBFluids ) Suggest topics for NephMadness ( Twitter ) Design of the COmbinatioN effect of FInerenone anD EmpaglifloziN in participants with chronic kidney disease and type 2 diabetes using a UACR Endpoint study (CONFIDENCE) ( PubMed ) Albuminuria-Lowering Effect of Dapagliflozin, Eplerenone, and Their Combination in Patients with Chronic Kidney Disease: A Randomized Crossover Clinical Trial ( PubMed ) Spitzer’s involvement in revolutionizing nephrology is part of this lecture I did at the University of Nebraska Diabetes Symposium. (Dropbox: Start on slide 29 ) Spitzer Resigns, Citing Personal Failings ( New York Times ) Tubular Secretions Swap : Dumb Money on NetFlix ( Wikipedia ) Josh : Hiking Zion National Park ( National Park Service ) Sophia : Lost in Space 2018 TV series on NetFlix ( Wikipedia ) Nayan : Pelican Hill resort ( Website ) Joel : Bodkin NephJC Summer Book Club : Covenant of Water by Abraham Verghese ( Amazon )…
F
Freely Filtered, a NephJC Podcast
1 Episode 70: Predicting Preeclampsia, the PRAECIS trial 1:16:20
1:16:20 Play Later Play Later Lists Like Liked1:16:20
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath AC Gomez Nayan Arora With Special Guest: Anuja Java , complement god and pre-eclampsia research ( Twitter ) Shannon M. Clark , MD, FACOG, an honest to god, true, maternal-fetal medicine specialist. ( Website | Instagram ) Editor Nayan Arora Show Notes CHIP Study from 2015 ( NEJM | NephMadness 2015 ) CHAP study from 2022 ( NEJM | NephJC ) NephMadness 2024 coverage of the diagnosis of preeclampsia sFlt background: Pathogenesis of Preeclampsia and Therapeutic Approaches Targeting the Placenta ( PubMed ) PlGF background: Perspectives on the Use of Placental Growth Factor (PlGF) in the Prediction and Diagnosis of Pre-Eclampsia: Recent Insights and Future Steps ( PubMed ) The PRAECIS trial ( NephJC | NEJM Evidence ) You may just want to listen to Anna Burgner discuss preeclampsia with Kenar Jhaveri and Koyal Jain ( GN in Ten ) for the NephMadness PodCrawl Bene Gesserit ( Wikipedia ) Pathogenesis of preeclampsia: the genetic component ( PubMed ) Tubular Secretions Swap Slow Horses on Apple TV ( Wikipedia ) AC Hidden Figures ( Amazon ) Nayan Baseball, little league Anuja Young Sheldon ( Wikipedia ) Joel Dune audiobook ( Amazon )…
F
Freely Filtered, a NephJC Podcast
1 Episode 69:DUPLEX Sparsentan, it’s no Acthar Gel 1:41:55
1:41:55 Play Later Play Later Lists Like Liked1:41:55
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Priya Yenebere Nayan Arora With Special Guest: Brendon Neuen Super smart guy and clinical trialist Michelle Rheault Lead author of DUPLEX and friend of the pod Show Notes Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis NephJC Summary | PubMed | NEJM KDIGO FSGS Guidelines 2021 ( PDF ) Characterization of the Clinical Evidence Supporting Repository Corticotropin Injection for FDA-Approved Indications, A Scoping Review ( JAMA Internal Medicine ) DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS ( PubMed ) Vlado Perkovic, mentor and sponsor extradenoire ( UNSW Sydney ) Shimer Its a floor wax and a desert topping ( TikTok ) SONAR: Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease: a double-blind, randomised, placebo-controlled trial. ( NephJC ) Travere Therapeutics Announces FDA Accelerated Approval of FILSPARIᵀᴹ (sparsentan), the First and Only Non-immunosuppressive Therapy for the Reduction of Proteinuria in IgA Nephropathy ( Travere press release ) GFR Slope: Chronic vs Total slope: A meta-analysis of GFR slope as a surrogate endpoint for kidney failure ( Nature Medicine ) There are dozens of us! Dozens! ( Know your Meme ) Brendon’s Neuen’s tweet about total versus chronic slope ( X | Twitter ) Julie R. Ingelfinger, deputy editor for the New England Journal of Medicine ( Wikipedia ) You know nothing, John Snow ( YouTube shorts ) Tubular Secretions Swapnil Foundation season two on Apple TV Wheel of Time season two Amazon Prime Brendon Andor Priya Poverty, by America Mattew Desmond Nayan The Armor of Light: A Novel by Ken Follett Michelle Lessons in Chemistry: A Novel by Bonnie Garmus…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 68: Inpatient hypertension 1:28:08
1:28:08 Play Later Play Later Lists Like Liked1:28:08
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Jordy Cohen AC Gomez With Special Guest: Tim Anderson @TimAndersonMD Editor: Priya Yenebere Show Notes Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults NephJC Summary | PubMed | JAMA Internal Medicine The Jordy AC collab: An Interactive Ambulatory Nephrology Curriculum for Internal Medicine Interns: Design, Implementation, and Participant Feedback ( PubMed ) Clinical Outcomes After Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge ( PubMed ) Trends in Blood Pressure Treatment Intensification in Older Adults With Hypertension in the United States, 2008 to 2018 ( PubMed ) Overlap Weighting: A Propensity Score Method That Mimics Attributes of a Randomized Clinical Trial ( JAMA Guide to Statistics and Methods ) Tubular secretions Swap The Dispatcher by John Scalzi ( Wikipedia ) AC A Heart that Works by Rob Delaney ( NYT Review ) Tim Demon Copperhead by Barbara Kingsolver ( Amazon ) Jordy The Anthropocene Reviewed: Essays on a Human-Centered Planet ( Amazon ) Joel The Dolomites for hiking n Northern Italy…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 67: NephMadness and Animal House 47:44
47:44 Play Later Play Later Lists Like Liked47:44
Play Later Play Later Lists Like LikedAnimal House Region NephMadness description by Tiffany Truong Editorial by Kelly Hyndman @DrKeeksPhD They May Look Cute, But Are All Animals Sweet? The Filtrate: Joel Topf Swapnil Hiremath Sophia Ambruso Josh Waitzman With Special Guest: Kelly Hyndman Editor: Sophia Ambruso Show Notes Animal House 2018 with Mark Zeidel, MD ( AJKDblog ) Animal House 2021 with Kelly Hyndman ( AJKDBlog ) Animal House 2022 with Kelly Hyndman ( AJKDBlog ) Mount Desert Island Summer Junket ( Website ) First person account go a Gila Monster bite ( YouTube ) Looks like Gila Hank, the gun toting mascot of Eastern Arizona College has been replaced by a non-gun toting Gila monster cowboy. Old logo ( Reddit ) | New logo ( Gila Valley Central Newspaper ) Discovery, characterization, and clinical development of the glucagon-like peptides ( Drucker JCI 2017 ) The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease ( Rossing NDT 2023 ) Semaglutide 1.0 mg demonstrates 24% reduction in the risk of kidney disease-related events in people with type 2 diabetes and chronic kidney disease in the FLOW trial ( Novo Nordisk ) King Gizzard & The Lizard Wizard - Gila Monster ( YouTube ) Eastern Arizona Campus Store Tubular Secretions Swap: Three Body Problem ( Wikipedia ) Josh: Animal Crossing ( Nintendo ) Sophie: Pyelonephritis in inflammatory bowel disease. Is this a thing? Joel: Maggie Moore(s) ( Wikipedia )…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 66: NephJC Summer Book Club 1:15:09
1:15:09 Play Later Play Later Lists Like Liked1:15:09
Play Later Play Later Lists Like LikedHow Medicine Works, and When It Doesn’t Amazon The Filtrate: Joel Topf Josh Waitzman Jennie Lin With Special Guest: Jade Teakell Perry Wilson Editor: Joel Topf Show Notes Understanding Medical Research: Your Facebook Friend is Wrong. Coursera Illusory truth effect ( Wikipedia ) Number needed to treat ( Wikipedia ) NNT at MedPage Today : NNT on NephJC Deaths of Despair: Suicide ( CDC 2001-2021 ) Drug Overdose ( CDC 2001-2021 ) Steve Jobs delayed therapy for his treatable pancreatic cancer ( ABC News ) Residents are unionizing at Mass General Brigham. Here's what you need to know ( WBUR ) Pi and bouncing bricks ( YouTube ) Doctors in New Zealand—the only non-U.S. country that allows DTC advertising—call for bans ( FiercePharma ) The Surgisphere Scandal: What Went Wrong? ( The Scientist ) VITAL SIGNS: FERTILITY; A Study Links Prayer and Pregnancy ( The New York Times ) Researcher Pulls His Name From Paper on Prayer and Fertility ( The New York Times ) Tubular Secretions Josh: Glomerular Nephritis by Thomas Addis ( Review in JAMA from 1948 ) Jennie: The Chicago Marathon Jade: The People’s Hospital ( Amazon ) Perry: Anathem by Neal Stephenson ( Amazon )…
F
Freely Filtered, a NephJC Podcast
The Filtrate: Joel Topf Nayan Aurora Sophia Ambruso With Special Guest: Michael Collins Editor: Nayan Aurora Show Notes: Twitter is now X ( NYT ) Michael Collins ( the astronaut , not the real one) PlasmaLyte by Baxter NephJC BEST Fluids summary Early Goal Directed Therapy for Sepsis NEJM manuscript which changed practice patterns and welcomed in an era of massive fluid resuscitation. PLUS Trial NEJM SPLIT Trial JAMA BaSICS NephJC Summary SALTED and SMART NephJC Summary Adaptive minimization wikipedia BEST Fluids statistical plan BEST Fluids in CLinicalTrials.gov Delayed Graft Function review in American Journal of Transplant Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis in NEJM Evidence A pragmatic, open-label, randomized controlled trial of Plasma-Lyte-148 versus standard intravenous fluids in children receiving kidney transplants (PLUTO) in Kidney International Tubular Secretion Nayan finally getting around to Succession on HBO Sophia autoimmune protocol diet Hawthorne Effect Michael Stephen Fry reading Harry Potter…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 064: Freely Filtered with The Curbsiders Live at Kidney Week! 1:32:08
1:32:08 Play Later Play Later Lists Like Liked1:32:08
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Sophia Ambruso AC Gomez Josh Waitzman Jennie Lin Nayan Arora The Curbsiders Matt F. Watto ( @DoctorWatto ) Paul Nelson Williams , America’s primary care physician ( @PaulNWilliamz ) With Special Guest: JD Foster ( @KidneyVet ) Sayed Tabatabai ( @TheRealDoctorT ) Nephrologist in Austin and the author of These Vital Signs Michelle Rheault ( @rheault_m ) Chief of Pediatric Nephrology at the University of Minnesota and lead author of the DUPLEX Trial Editor: Joel Topf Show Notes: Lily toxicity in the cat ( PubMed ) Surgeons perform kidney transplants in cats amid rising demand for advanced pet care ( ABC News ) Treatment of ibuprofen toxicity with serial charcoal hemoperfusion and hemodialysis in a dog ( PubMed ) Nephrology in Veterinary Medicine ( Kidney 360 ) Star Wars Society of San Antonio ( FaceBook ) These Vital Signs ( Amazon ) Dr Tabatabai read a short story called The Handholder, here is the original tweet thread for that story ( ThreadReader ) The pearl not the patient ( PubMed ) Late Braking and High Impact Clinical Trial press release MENTOR, Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy, was in 2019 not 2017 ( NEJM ) KALM-1, A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus, was in 2019 not 2017 ( NEJM ) Sophie’s number one pick : Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial ( Lancet ) Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). Clinical Trial Considerations in Developing Treatments for Early Stages of Common, Chronic Kidney Diseases: A Scientific Workshop Cosponsored by the National Kidney Foundation and the US Food and Drug Administration ( AJKD ) AC Gomez’s Pick : MDR-101-MLK Update: Operational Immune Tolerance Achieved in Living Related HLA-Matched Kidney Transplant Recipients ( ASN-Online.org ) Josh’s Pick : A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy ( NEJM ) Nayan’s Pick : The EnAKT LKD Cluster Randomized Clinical Trial ( JAMA Internal Medicine ) The Freely Filtered simultaneous release ( NephJC ) Freely Filtered is now a verb. Swap’s Pick : Strategies for the Management of Atrial Fibrillation in PatiEnts Receiving Dialysis (SAFE-D) ( ASN-Online.org ) Joel’s Pick : AYAME Study: Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Bardoxolone Methyl in Diabetic Kidney Disease (DKD) Patients ( ASN-Online.org ) Reata is a no-show to the 2012 ASN Kidney Week ( PBFluids ) Michelle’s Pick : Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis. The DUPLEX Study ( NEJM ) DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS ( PubMed )…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 063: Late Breaking and High Impact Clinical Trial Simultaneous Release! 2:05:22
2:05:22 Play Later Play Later Lists Like Liked2:05:22
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Sophia Ambruso AC Gomez With Special Guest: Amit Garg ( @AmitXGarg ) Nephrologist at Western University, London, and lead PI of the EnAKT LKD trial. Susan Q. McKenzie ( LinkedIn ) Co-Founder & Chair, Transplant Ambassador Program. President of the Kidney Patient and Donor Alliance of Canada. Editor: Joel Topf Show Notes: Late Braking and High Impact Clinical Trial press release JAMA Internal Medicine MyTEMP trial Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial ( PubMed | NephJC | Freely Filtered ) Transplant is cheaper! An economic assessment of contemporary kidney transplant practice ( PDF ) Transplant is better! Survival for waitlisted kidney failure patients receiving transplantation versus remaining on waiting list: systematic review and meta-analysis ( PubMed ) Transplant disparities Association of Race and Ethnicity With Live Donor Kidney Transplantation in the United States From 1995 to 2014 ( PubMed ) MUC1 Kidney Disease Autosomal Dominant Tubulointerstitial Kidney Disease: An Emerging Cause of Genetic CKD ( Kidney International Reports ) This study has all the adjectives: “We conducted a pragmatic , two-arm , parallel-group , open-label , registry-based , superiority , cluster - randomized clinical trial.” Explore Transplant by Amy Waterman, PhD Transplant Ambassador Program Kidney Failure Risk Equation A Predictive Model for Progression of Chronic Kidney Disease to Kidney Failure ( JAMA | Calculator ) The complete protocol A Quality Improvement Intervention to Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) in Patients With Chronic Kidney Disease: Clinical Research Protocol of a Cluster-Randomized Clinical Trial ( PDF ) Pre-published statistical plan Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD): Statistical Analysis Plan of a Registry-Based, Cluster-Randomized Clinical Trial ( PubMed ) Hawthorne effect ( Wikipedia ) The Advancing American Kidney Health Initiative “Aim for 80% of new American ESRD patients in 2025 receiving either home dialysis or a transplant” ( NKF ) Tubular Secretions Swapnil The Time Travelers Wife by Audrey Niffenegger ( Wikipedia ) and HBO movie of the same name ( Wikipedia ). Sophia The Wheel of Time streaming on Amazon ( Wikipedia ) based on the series of books of the same name by Robert Jordan and Brandon Sanderson. Susan The Woman Who Loved Giraffes movie ( Website ) Amit Canadians cannot get Visas to visit India ( Reuters ) AC Eagles are good at Football ( Fox Sports ) and Alport Connect Meeting in San Diego ( Alport Syndrome Foundation Website ) Joel Live podcast recording at Kidney Week ( NephJC )…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 062: Inaxaplin for APOL1 Kidney Disease 1:31:17
1:31:17 Play Later Play Later Lists Like Liked1:31:17
Play Later Play Later Lists Like LikedF
Freely Filtered, a NephJC Podcast
1 Freely Filtered 061: Bicarb in Transplant 1:18:11
1:18:11 Play Later Play Later Lists Like Liked1:18:11
Play Later Play Later Lists Like LikedBicarbonate did not slow the loss of GFR in this well done Swiss, single-blind study of transplant patients. The Filtrate: Joel Topf Nayan Arora Swapnil Hiremath Pirya Yenebere With Special Guest: Nav Tangri nephrologist and epidemiology at the University of Manitoba Editor: Nayan Arora Show Notes: Arsenal FC The London study that kicked it all off! de Brito-Ashurst, I., Varagunam, M., Raftery, M. J., & Yaqoob, M. M. (2009). Bicarbonate supplementation slows progression of CKD and improves nutritional status . Journal of the American Society of Nephrology: JASN, 20(9), 2075–2084. The multi center (but unblinded) UBI Study with mortality benefit! Di Iorio, B. R., Bellasi, A., Raphael, K. L., Santoro, D., Aucella, F., Garofano, L., Ceccarelli, M., Di Lullo, L., Capolongo, G., Di Iorio, M., Guastaferro, P., Capasso, G., & UBI Study Group. (2019). Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study . Journal of Nephrology, 32(6), 989–1001. The BiCARB Study: Double blinded and negative BiCARB study group. (2020). Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial . BMC Medicine, 18(1), 91. The initial Veverimer Study Wesson, D. E., Mathur, V., Tangri, N., Stasiv, Y., Parsell, D., Li, E., Klaerner, G., & Bushinsky, D. A. (2019). Long-term safety and efficacy of veverimer in patients with metabolic acidosis in chronic kidney disease: a multicentre, randomised, blinded, placebo-controlled, 40-week extension . In The Lancet (Vol. 394, Issue 10196, pp. 396–406). doi.org/10.1016/s0140-6736(19)31388-1 The Valor CKD trial is still unpublished. But here is the press release . VALOR-CKD design manuscript The study of the night: Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomized, single-blind, placebo-controlled, phase 3 trial NephJC | PubMed | Lancet Alkali with normal bicarb? Sure, take a look at: Goraya, N., Simoni, J., Jo, C., & Wesson, D. E. (2012). Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy . Kidney International, 81(1), 86–93. Metforminator! The BASE Trial: Raphael, K. L., Isakova, T., Ix, J. H., Raj, D. S., Wolf, M., Fried, L. F., Gassman, J. J., Kendrick, C., Larive, B., Flessner, M. F., Mendley, S. R., Hostetter, T. H., Block, G. A., Li, P., Middleton, J. P., Sprague, S. M., Wesson, D. E., & Cheung, A. K. (2020). A Randomized Trial Comparing the Safety, Adherence, and Pharmacodynamics Profiles of Two Doses of Sodium Bicarbonate in CKD: the BASE Pilot Trial . Journal of the American Society of Nephrology: JASN, 31(1), 161–174. Tubular Secretions Swap The Three-Body Problem (novel) | Netflix Nayan Women’s World Cup Tangri English Premier Soccer and Inflation Priya Silo on Apple TV Joel Live Podcast recording at ASN Kidney…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 059: Furosemide v Torsemide 1:02:29
1:02:29 Play Later Play Later Lists Like Liked1:02:29
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Nayan Arora Sophia Ambruso With Special Guest: Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA. His Google Schoolar page is better than yours. And returning for her fourth time (why do we keep inviting her back?) Sadiya Khan @heartDocSadiya Assistant Professor of Medicine (Cardiology) and Preventative Medicine at Northwestern Feinberg School of Medicine. Link Editor: Priya Yenebere Show Notes: Diuretic Therapy review by. Craig Brater NEJM The manuscript in JAMA | NephJC Metoprolol vs Carvedilol: Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial ( Lancet ) EMPULSE: The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial ( Nature Medicine ) Effect of Aliskiren on Postdischarge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure The ASTRONAUT Randomized Trial Effects of Oral Tolvaptan in Patients Hospitalized for Worsening Heart Failure The EVEREST Outcome Trial Sophia ended up placing fifth in NephMadness 2023. ( Link ) Joel finished 697th After winning in the opening round, Northwestern lost to UCLA, in the second round of the March Madness tournament, 68-63. Torsemide to furosemide equivalents CardioMems positive trial: Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial ( The Lancet ) CardioMems negative trial: Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial ( The Lancet ) Estimation of the Absolute Risk of Cardiovascular Disease and Other Events: Issues With the Use of Multiple Fine-Gray Subdistribution Hazard Models ( Circulation ) Torasemide in chronic heart failure: results of the TORIC study ( PubMed ) Tubular Secretions Nayan: Louise Penny A World of Curiosities: A Novel ( Amazon ) Sadiya: Ted Lasso season three Sophia: The Last of Us on HBO and SNL skit Mario Cart as Prestige Drama Boback: Duolingo for Japanese…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 060: HCTZ v Kidney Stones, The NOSTONE trial 1:42:42
1:42:42 Play Later Play Later Lists Like Liked1:42:42
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Nayan Arora Sophia Ambruso With Special Guest: Megan Prochaska Assistant professor of medicine at University of Chicago John Asplin Medical Director Consultant LithoLink ( Twitter ) Editor: Joel Topf Show Notes: The LithoLink website Stone Camp tweet Prevention of Repeated Episodes of Kidney Stones in Adults: A Clinical Practice Guideline From the American College of Physicians ( link ) NOSTONE in the NEJM and NephJC Fred Coe Google Scholar | YouTube | Blog Hypercalcuria. Curhan et al. 24-h uric acid excretion and the risk of kidney stones PubMed EQUIL2 software to evaluate urinary super saturation Anna Zisman Racial Differences in Risk Factors for Kidney Stone Formation ( CJASN ) Potassium Citrate on GoodRx Moonstone Nutrition Potassium and citrate by Fred Coe ( blog ) Thiazide Diuretics and Fracture Risk: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials ( PubMed ) Chlorthalidone promotes mineral retention in patients with idiopathic hypercalciuria by Coe et al ( PubMed ) NHANES 24-hour urine Na ( Abstract ) Kidney Stone risk is reduced with empagliflozin ( PubMed ) Prospective trial to determine the effect of SGLT2i on urinary supersaturation ( BMJ Open ) GLP agonists and kidney stone risk Tubular Secretions Swap: Star Wars: Thrawn Series by Timothy Zahn ( Penguin Random House ) Josh: Little League Megan: Renal related podcasts Sophia Renal Stone Camp and ABCKidney.com Nayan: Ted Lasso Robert Galbraithand The Comoran Strike Novels ( home page ) John: Fred Coe’s Blog Joel: Spiderman across the Spider-Verse ( Wikipedia )…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 057: NephMadness 2023 TMA 1:21:41
1:21:41 Play Later Play Later Lists Like Liked1:21:41
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Sophia Ambruso With Special Guest: Anna Vinakova Associate Professor of Medicine at Virginia Commonwealth University. NephMadness Executive. Vanuja Java is a transplant nephrologist at Washington University in St. Louis, MO. Her research involves functional characterization of genetic variants in complement-mediated diseases. She co-chairs the ClinGen complement gene curation expert panel. Editor: Sophia Ambruso Show Notes: #NephMadness 2023: Thrombotic Microangiopathy Region TMA Review article in the NEJM from 2014: Syndromes of Thrombotic Microangiopathy Dr. Anuja Java Co-chairs Working Group in an International Committee for Revising aHUS Nomenclature Nephrology Secrets 4th Edition at Amazon University of Iowa Genetic testing for aHUS Early Eculizumab Withdrawal in Patients With Atypical Hemolytic Uremic Syndrome in Native Kidneys Is Safe and Cost-Effective: Results of the CUREiHUS Study. KI reports . This is the Netherlands study. They used home urine dipsticks to monitor for relapses. Clinical promise of next-generation complement therapeutics Nature reviews. Drug Discovery NephMadness Podcrawl Tubular Secretions Swap: Neuromancer and the works of William Gibson ( @GreatDismal ) Sophia: The Magicians on Netflix Anna: Recommends nephrology. Says it is awesome. Anuja: Dope Sick on Hulu and Women in Nephrology mentor program Josh: Mobituaries with Mo Rocca . Specifically “ Death of a Banana ” Joel: Ivory by TapBot…
F
Freely Filtered, a NephJC Podcast
Welcome to the NephMadness PodCrawl The idea behind a podcrawl is for a variety of podcasts to coordinate on timing and topic to push a theme and get each other’s listeners to explore all of the podcasts. One of the first goals behind NephMadness was to build a community and in the early years of Twitter, NephMadness was central to the formation of #NephTwitter and defining the ethos that makes our online community kind, intelligent, vibrant, and interesting. The NephMadness Podcrawl hopes to inspire and grow the nephrology podcast community in the same way. For 2023, our second year, the PodCrawl has assembled the Avengers of Medical Pods! Go to NephMadness.com/podcrawl for more information and links to all of the podcasts! The Curbsiders gets the skinny on mineralcorticoid receptor antagonists Core IM will be covering Kidney Transplant in their classic Five Pearl format The CardioNerds will be covering the effect of Heart Failure Devices on Kidney Health Freely Filtered will try to understand thrombotic microangiopathy ISN Global Kidney Care goes deep on IgA nephropathy The Cribsiders look at transitions, first the Peditrics to Adult nephrology transition and then from living to death with palliative nephrology Fellow on Call will be covering Onconephrology And finally, The Nephron Segment looks at Transgender Health and CKD…
F
Freely Filtered, a NephJC Podcast
The Filtrate: Joel Topf Swapnil Hiremath Nayan Arora Sophia Ambruso With Special Guest: Amit Garg @AmitXGarg , Nephrologist at Western University, London, and lead PI of the MYTEMP trial. Editor: Joel Topf Show Notes: MyTEMP in pubmed: Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial MyTEMP Summary on NephJC It’s really cold in Ontario The NephTrials blog summary on Pragmatic Trials The pragmatic TiME trial on longer time on dialysis (ahem, sabotaged by site investigators like Joel who cut dialysate time) Dember et al in JASN Poor quality of trial data preceding MyTEMP, a systematic review from Mustafa et al in JASN The 2007 European Best Practice Guideline (EBPG) from 2007, recommending “Cool dialysate temperature dialysis (35–36°C) or isothermic treatments by blood temperature controlled feedback should be prescribed in patients with frequent episodes of IDH (Evidence level I).” in NDT 47% of centres from a DOPPS study of 273 centers routinely use of lower dialysate temperature, Dasgupta et al in JASN How do you convert from C to F? Almanac.com (35.5 C is 96.9 F; 37 C is 98.6 F) More on the rationale and design of MyTEMP: Al-Jaishi et al in CJKHD How big is 4.3 million (the number of hemodialysis treatments in MyTEMP)? Very big indeed . NephJC discussion of another cluster RCT and granular data only on a subset SSASS Participants in dialysis clinical trials are not representative of the real world dialysis cohorts, Smyth et al in JAMA Int Med Peritoneal dialysis numbers in Ontario are high, Blake et al in PDI , though with ~ 60% CVC rates, Blake et al in Kidney360 Dialysate Magnesium #DreamRCT from Swap, NephTrials discussion of DialMag Statistical analysis plan of MyTEMP, Dixon et al in CJKHD Tubular Secretions Swap: Watch Everything, Everywhere All At Once on Prime Nayan: Read The Midnight Ride from Ben Mezrich (brother of Josh Mezrich from the NephJC Summer Book Club 2021 ) Sophia: Making nephrology education fun at the UC Denver Amit: The wrestling team at Western U from 1990-91 Joel: House of the Dragon on HBO Max…
F
Freely Filtered, a NephJC Podcast
The Filtrate: Joel Topf Swapnil Hiremath Jordy Cohen With Special Guest: Laurie Tomlinson . @Roxytonin Nephrologist at University Hospitals Sussex and research hero of Jordy. Editor: Priya Yenebere Show Notes: STOP-ACE in pubmed: Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease STOP-ACE Summary in NephJC Prior data showing preservation of renal function by stopping ACEi: The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney disease Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency: NEJM Dr. Tomlinson’s article on creatinine changes in RASi from 2017: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study NephJC | PubMed Accuracy of eGFR at low GFR: A new equation to estimate glomerular filtration rate Strong opinions, loosely held. “Permissive AKI” with treatment of heart failure . Editorial by Chirag Parish and Steven Coca The rational for NICE avoiding RASi in black patients: Hypertension and ethnic group AASK trial showing superiority of RASi in African Americans. JAMA ALLHAT post-hoc analysis of outcomes by self-reported race. JAMA | PubMed Sophisticated Swedish observational study that Swap loved. Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study Target Trials in Nephrology Dr Edouard Fu grand rounds at Ottawa Nephrology, YouTube Target Trial EmulationA Framework for Causal Inference From Observational Data by Miguel Hernán in JAMA Tubular Secretions Jordy: Third season of His Dark Materials on HBO Swap: Movies by Wes Anderson on Disney Plus Laurie: The Book, “ Nearly All the Men in Lagos are Mad ” Jordy: How Medicine Works and When It Doesn't: Learning Who to Trust to Get and Stay Healthy | Amazon Joel EO | NYT Review…
F
Freely Filtered, a NephJC Podcast
The Filtrate: Joel Topf Swapnil Hiremath Josh Waitzman Sophia Ambruso Priya Yenebere With Special Guest: Brendon Neuen , Secretariat of the SGLT2 Trialists Consortium and cool guy on Twitter . Editor: Sophia Ambruso Show Notes: Joel’s Conflict of Interest Statement. Sophia is also conflicted with Astra Zeneca and Brendon with everybody in the SGLT2i space. Joel starts off with a history of SGLT2i EMPA-REG Outcomes . First! CANVAS . OMG this signal is reproducible! CREDENCE ( 🎧 ). It works in a dedicated population at high risk of kidney disease. And in a study designed for renal end-points. DAPA-CKD ( 🎧 ). It’s not just for diabetics! EMPA-Kidney. It works at really low GFR. And without albuminuria. And again in non-diabetics. SGLT Inhibitors for Type 1 Diabetes: Proceed With Extreme Caution Click to find the supplement (requires a subscription) Differences in definition in the decreased renal function component of the composite primary outcomes. EMPA-Kidney 40% DAPA-Kidney 50% CREDENCE doubling of serum Cr Usability Testing of a Sick-Day Protocol in CKD ( Pubmed ) New Guidelines for Statistical Reporting in the Journal ( link , commentary on said guidelines by Frank Harrell) CKD outcomes and the FDA: Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency The Peripheral on Amazon Prime Unsealed the Tylenol Murders Podcast Project Hail Mary by Andrew Weir Lizzy McAlpine Singer Song Writer Rachel Maddow Presents: Ultra Twitter chaos continues. Get your Med-Mastodon handle…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 053: The Kidney Week Draft 1:04:34
1:04:34 Play Later Play Later Lists Like Liked1:04:34
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Nayan Arora Sophia Ambruso Editor: Nayan Arora Show Notes: Joel’s Conflict of Interest Statement The Draft Board EMPA-Kidney is “off the board” Lunch Symposium on Current and Future Approaches to the Diagnostic Assessment and Management of AKI in Patients with Cirrhosis provided by an educational grant from Mallinckrodt Pharmaceuticals The CONFIRM Trial Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome in NephJC Clinical Practice Session Leveraging Social Media to Create, Learn, Teach, Advocate, and Dispel Misinformation The BEST-Fluids Trial: A Randomized Controlled Trial of Balanced Crystalloid Solution vs. Saline to Prevent Delayed Graft Function in Deceased Donor Kidney Transplantation - Michael G. Collins, Magid Fahim, Elaine Pascoe, Carmel Hawley, David W. Johnson, Philip A. Clayton, Steven J. Chadban ( ClinicalTrials.gov ) The Late Breaking and High Impact Trials Session line up Stop ACEi CLARITY Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial Effects of Pantoprazole on Kidney Outcomes: Post Hoc Analyses From the COMPASS Randomized Controlled Trial by Lonnie Pyne, et al No Stone : Hydrochlorothiazide for the Prevention of Kidney Stone Recurrence by Daniel Foster, et al MyTEMP : Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial Clinical Practice Session Best of NephJC “We'd Now Like To Open The Floor To Shorter speeches disguised as questions.” ASN Task Force on the Future of Nephrology Attracting Osteopathic Medical Students Into Nephrology Hasan Minhaj’s joke at the expense of DOs TRANSFORM-HF: Torsemide vs. Furosemide in Treating Patients With HF Point-of-Care Ultrasound in Nephrology specifically VExUS…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 052: Acetazolamide for Acute Decompensated Heart Failure (ADVOR) 1:09:56
1:09:56 Play Later Play Later Lists Like Liked1:09:56
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Jordy Cohen Nayan Arora Sophia Ambruso Special Guests: Boback Ziaeian @boback Assistant Professor of Medicine David Geffen School of Medicine at UCLA returns for his second episode ( SODIUM-HF ). His Google Schoolar page is better than yours. David Ellison @dhekidney is professor of medicine at Oregon Health Science University and head of the Oregon Clinical & Translational Institute. Show Notes: Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome ( The CARESS Trial ) Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure ( The UNLOAD trial ) Diuretic Strategies in Patients with Acute Decompensated Heart Failure ( The DOSE Trial ) Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure ( The 3T Trial ) Sequential nephron blockade with a thiazide diuretic has a 1 B-NR (non-radomized) grade in the AHA/ACC Heart Failure Guidelines (7.2) Three important acute decompensated heart failure with SGLT2i: 1. Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure ( SOLOIST-WHF Trial ) 2. The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial ( The EMPULSE Trial ) 3. Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure ( EMPAG-HF ) Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review Cardiologist Sues Epic Over Copyright Infringement Outcomes associated with a strategy of adjuvant metolazone or high-dose loop diuretics in acute decompensated heart failure: a propensity analysis . Acetazolamide to increase natriuresis in congestive heart failure at high risk for diuretic resistance ( PubMed ) Efficacy and Safety of Spironolactone in Acute Heart Failure ( ATHENA Trial ) Joel with a video on acetazolamide for altitude sickness . The Butchering Art: Joseph Lister's Quest to Transform the Grisly World of Victorian Medicine(Amazon)…
F
Freely Filtered, a NephJC Podcast
1 Freely Filtered 051: Pip Tazo and Vanco: Nephrotoxin or Not so toxic 1:09:45
1:09:45 Play Later Play Later Lists Like Liked1:09:45
Play Later Play Later Lists Like LikedThe Filtrate: Joel Topf Swapnil Hiremath Nayan Arora Priya Yenebere Special Guests: Todd Miano, PharmD, PhD @Miano81 Assistant Professor of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine. Show Notes: Early Pip/Tazo article showing nephrotoxicity . Covered by NephJC Linazolid vs Vanco RCT showing excess AKI with Vanco. Yes Vance is a lot less toxic than it was in the Mississippi mud days but your attending telling you it is no longer nephrotoxic is wrong. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study and Vancomycin and the Risk of AKI: A Systematic Review and Meta-Analysis . Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine Vancomycin-Associated Cast Nephropathy: Reality or Fantasy? Molecular Epidemiology of SepsiS in the ICU (MESSI) prospective cohort. Learn about it her: A multibiomarker-based outcome risk stratification model for adult septic shock* Cystatin C in acute kidney injury Changing Definitions of Sepsis Proposed new definitions of AKI incorporating biomarkers: Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference. A Consensus Statement in JAMA Network Open Applications of propensity score methods in observational comparative effectiveness and safety research: where have we come and where should we go? The effect of glucocorticoids on serum cystatin C in identifying acute kidney injury: a propensity-matched cohort study Protective effect of piperacillin against nephrotoxicity of cephaloridine and gentamicin in animals PulmCrit – Myth-busting the conditional nephrotoxicity of piperacillin-tazobactam by Josh Farkas Sharp Objects on Good Reads Bandon Dunes The Ocean Course at Kiawah Island Golf Resort Be Real follow me: BeRe.al/kidney_boy SNL spoof of BeReal…
F
Freely Filtered, a NephJC Podcast
The Filtrate: Joel Topf Swapnil Hiremath Jennie Lin Special Guests: Priya Yenebere @PriRenalAKI Transplant nephrologist at Indiana University School of Medicine. She is a current NSMC Intern. J Pedro Teixeira @NephCrit_NM ICU Nephrologist at the University of New Mexico. Editor: Priya Yenebere Show Notes: Critical Care Nephrology Critical Care Nephrology: Core Curriculum 2020 by Benjamin R Griffin, Kathleen D Liu, and J Pedro Teixeira. Critical Care Rheumatology Dual-Trained Rheumatologists Take Multidisciplinary Approach to Their Patients Med-Peds to Nephrology Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock by Emanuel Rivers ProMISe: Trial of Early, Goal-Directed Resuscitation for Septic Shock ARISE: Goal-Directed Resuscitation for Patients with Early Septic Shock ProCESS: A Randomized Trial of Protocol-Based Care for Early Septic Shock The Filtrate: Rinaldo Bellomo and micro circulatory disorders as cause of AKI in sepsis. Septic acute kidney injury: new concepts Comparison of Two Fluid-Management Strategies in Acute Lung Injury (FACTT) The negative trial we accept as a positive trial because of the secondary outcomes. The prime minister of Finland was caught on the dance floor. This is a bad thing? ( NY Times ) Deferred Consent: A New Approach for Resuscitation Research on Comatose Patients Lactate conversion MediCalc The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Mottling score is a strong predictor of 14-day mortality in septic patients whatever vasopressor doses and other tissue perfusion parameters Critical Care Reviews Podcast: CLASSIC Trial Results Presentation What is the most George Constanza-esque reason you broke up with someone? ( reddit ) Bonferroni correction The Importance of Fluid Management in Acute Lung Injury Secondary to Septic Shock Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery in the NEJM. RELIEF , NephJC discussion Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial in JAMA FEAST Trial: Mortality after Fluid Bolus in African Children with Severe Infection Rings of Power on Amazon Prime Why the Hobbit trilogy sucked Industry on HBO Sandman 2022 on Netflix Where did Liverpool FC go wrong with the 2021/2022 Premier League? ( Quora ) CRRT Academy at University of Alabama with 2020 Robert G. Narins Award Recipient: Ashita Tolwani, MD, MS ( YouTube ) Life as a Nephrologist podcast on CritCare Nephrology Continuous KRT: A Contemporary Review by J. Pedro Teixeira, Javier A. Neyra and Ashita Tolwani University of New Mexico Nephrology Program . Apply to their fellowship. The Pledge Drive is over, but you can always support NephJC . NephJC is a 501(3)c registered non-profit and all donations are tax deductible in the US.…
Welcome to Player FM!
Player FM is scanning the web for high-quality podcasts for you to enjoy right now. It's the best podcast app and works on Android, iPhone, and the web. Signup to sync subscriptions across devices.
Daily Deals
Similar to Freely Filtered, a NephJC Podcast
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Emergency Medicine Cases – Where the Experts Keep You in the Know. For show notes, quizzes, videos and more learning tools please visit emergencymedicinecases.com
…
continue reading
Come dive into one of the curiously delightful conversations overheard at National Geographic’s headquarters, as we follow explorers, photographers, and scientists to the edges of our big, weird, beautiful world. Hosted by Peter Gwin and Amy Briggs.
…
continue reading
The BMJ brings you interviews with the people who are shaping medicine and science around the world.
…
continue reading
Help me fill in the blanks of the practice of ED Critical Care. In this podcast, we discuss all things related to the crashing, critically ill patient in the Emergency Department. Find the show notes at emcrit.org.
…
continue reading
Science Friction has a new series: Cooked. We dig into food science pickles. Why are studies showing that ice cream could be good for you? Do we really need as many electrolytes as the internet says? And why are people feeling good on the carnivore diet? Nutrition and food scientist Dr Emma Beckett takes us through what the evidence says about food categories and ingredients like meat, dairy and salt — and unpick why nutrition studies can be so conflicting and confusing. Airs Wednesday 11:30 ...
…
continue reading
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
…
continue reading
How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
…
continue reading
Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
…
continue reading
We humans could have a bright future ahead of us that lasts billions of years. But we have to survive the next 200 years first. Join Josh Clark of Stuff You Should Know for a 10-episode deep dive that explores the future of humanity and finds dangers we have never encountered before lurking just ahead. And if we humans are alone in the universe, if we don't survive intelligent life dies out with us too.
…
continue reading
Player FM - Podcast App
Go offline with the Player FM app!
Go offline with the Player FM app!
