The Human Upgrade With Dave Asprey podcast

#Wellness #Nutrition #Meditation #Lifestyle #Hacking #Fat #Diet #Brain #Biohacking #Dave Asprey #Fitness #Health and Well-Being #Self-Improvement #Fasting #Science #Podcasting Education

26:18

How do you know when it’s time to make your next big career move? With International Women’s Day around the corner, we are excited to feature Avni Patel Thompson, Founder and CEO of Milo. Avni is building technology that directly supports the often overlooked emotional and logistical labor that falls on parents—especially women. Milo is an AI assistant designed to help families manage that invisible load more efficiently. In this episode, Avni shares her journey from studying chemistry to holding leadership roles at global brands like Adidas and Starbucks, to launching her own ventures. She discusses how she approaches career transitions, the importance of unpleasant experiences, and why she’s focused on making everyday life easier for parents. [01:26] Avni's University Days and Early Career [04:36] Non-Linear Career Paths [05:16] Pursuing Steep Learning Curves [11:51] Entrepreneurship and Safety Nets [15:22] Lived Experiences and Milo [19:55] Avni’s In Her Ellement Moment [20:03] Reflections Links: Avni Patel Thompson on LinkedIn Suchi Srinivasan on LinkedIn Kamila Rakhimova on LinkedIn Ipsos report on the future of parenting About In Her Ellement: In Her Ellement highlights the women and allies leading the charge in digital, business, and technology innovation. Through engaging conversations, the podcast explores their journeys—celebrating successes and acknowledging the balance between work and family. Most importantly, it asks: when was the moment you realized you hadn’t just arrived—you were truly in your element? About The Hosts: Suchi Srinivasan is an expert in AI and digital transformation. Originally from India, her career includes roles at trailblazing organizations like Bell Labs and Microsoft. In 2011, she co-founded the Cleanweb Hackathon, a global initiative driving IT-powered climate solutions with over 10,000 members across 25+ countries. She also advises Women in Cloud, aiming to create $1B in economic opportunities for women entrepreneurs by 2030. Kamila Rakhimova is a fintech leader whose journey took her from Tajikistan to the U.S., where she built a career on her own terms. Leveraging her English proficiency and international relations expertise, she discovered the power of microfinance and moved to the U.S., eventually leading Amazon's Alexa Fund to support underrepresented founders. Subscribe to In Her Ellement on your podcast app of choice to hear meaningful conversations with women in digital, business, and technology.…

The Human Upgrade with Dave Asprey

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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human Upgrade™.

You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.

Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.

Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.

1330 episodes

The Human Upgrade with Dave Asprey

301,353 subscribers

updated 2 days ago

Series home•Feed

Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.

Join The Human Upgrade™ with Dave Asprey on this next evolution to upgrade your mind, body and life.

1330 episodes

#Wellness #Nutrition #Meditation #Lifestyle #Hacking #Fat #Diet #Brain #Biohacking #Dave Asprey #Fitness #Health and Well-Being #Self-Improvement #Fasting #Science #Podcasting Education

Tous les épisodes

The Human Upgrade with Dave Asprey

1
This Is Your Brain on 2025: The Biohacker’s Guide to Mental Clarity & Mood | Dr. Drew Ramsey : 1263 1:11:07

2 days ago1:11:07

1:11:07

You think you’re optimizing your brain—but what if the real culprit behind your brain fog, anxiety, and burnout is the modern world itself? In this episode, Columbia University psychiatrist and nutritional neuroscience pioneer Dr. Drew Ramsey joins Dave Asprey to decode the biological chaos hijacking your mind—and how to fight back. From inflammation and gut dysbiosis to screen-induced disconnection and hidden trauma, this is the ultimate roadmap for healing the modern brain. You’ll explore the cutting-edge science of neuroplasticity, discover how movement and social connection trigger brain growth, and learn why food is still your most powerful antidepressant. Plus: dancing, psychedelics, kale debates, and why porn is quietly reshaping the male brain. What You’ll Discover in This Episode: • Why brain fog, anxiety, and mood swings might be signs your brain is inflamed • How movement—especially dancing—can literally help your brain grow stronger • What your gut has to do with your mental health (and why some “healthy” foods can backfire) • The truth about antidepressants, supplements, and why there’s no one-size-fits-all fix • Why porn, ultra-processed food, and doomscrolling are silently wrecking focus and drive • A new way to think about mental fitness—like a workout plan for your brain SPONSORS -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • A Day of Biohacking and Consciousness Event April 12th: https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Drew’s Instagram : https://www.instagram.com/drewramseymd/?hl=en • Drew’s Linktree : https://shorturl.at/CIIR5 • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 01:43 – Intro • 02:51 – The State of Mental Health Today • 04:00 – Nutritional Psychiatry and Personal Experiences • 05:21 – Environmental Factors and Brain Health • 05:55 – Chemical Balance and Psychiatry • 09:19 – Mental Fitness and Connection • 14:17 – Modern Brain Challenges • 16:26 – The Role of Movement and Dance • 22:44 – Sex, Relationships, and Mental Health • 34:02 – Microbiome and Mental Health • 36:50 – Transitioning to Urban Life and Mental Health • 37:29 – The Role of Nature in Mental Well-being • 38:14 – Personal Experiences with Gut Health • 39:45 – Trial and Error in Mental Health • 42:16 – Cognitive Resilience and High Performance • 45:37 – The Importance of Family Meals • 46:33 – Challenges of Rural and Urban Living • 47:53 – Brain Health: Beyond Neurons • 49:01 – Neuroplasticity and Mental Fitness • 52:50 – Biohacking Mental Health • 57:31 – The Role of Serotonin in Depression • 01:03:57 – Debating the Benefits of Kale • 01:12:03 – Final Thoughts on Mental Health and Resilience See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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The Science of Consciousness: What’s Beyond the Brain? | Mark Gober : 1262 1:27:52

7 days ago1:27:52

1:27:52

You think, you feel, you are —but what if your consciousness isn’t just in your brain? What if reality itself is shaped by something beyond the physical? In this episode, Mark Gober—author, consciousness researcher, and former Silicon Valley banker—joins Dave Asprey to challenge everything you think you know about the mind, reality, and human potential. He explores groundbreaking research on near-death experiences, psychic phenomena, and why some scientists believe consciousness may exist beyond the body. Mark reveals how declassified CIA documents, quantum physics, and meditation practices point to a deeper, more interconnected world—one where perception creates reality. If you’ve ever questioned whether free will is an illusion, wondered about life after death, or wanted to tap into higher states of awareness, this episode will shift your perspective. What You’ll Discover in This Episode: • Is consciousness non-local? Why your brain might not be the source of your thoughts • Near-death experiences & life after death —the science and firsthand accounts • Psychic phenomena & remote viewing —what the CIA doesn’t want you to ignore • Float tanks, meditation & altered states —how to access expanded awareness • The AI consciousness debate —can machines ever become truly self-aware? • Protecting your energy —why spiritual safeguards matter when exploring altered states SPONSORS -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • A Day of Biohacking and Consciousness Event April 12th: https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Mark’s Instagram : https://www.instagram.com/markgober_author/ • Mark’s Websit e : https://www.markgober.com/ • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: 00:00 - Trailer 00:50 - Intro 03:11 - Meet Mark Gober 05:25 - From Banking to Awakening 10:16 - Float Tanks & Consciousness 12:35 - Psychic Phenomena 19:14 - Science & Skepticism 25:51 - Personal Experiences 40:51 - Spiritual Protection 42:58 - Parasitic Entities 44:59 - Psychedelics & Mindset 45:58 - Alien Abductions 47:04 - Navigating Psychedelics 51:58 - Intuition & Inner Knowing 58:41 - Telepathy & Remote Viewing 59:46 - Near-Death Experiences 01:04:54 - Consciousness Beyond the Brain 01:12:38 - Psychic Abilities & Ethics 01:24:11 - Consciousness & Reality 01:27:58 - Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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The Hidden Cost of Being Too Nice: Why People-Pleasing is Silently Killing Your Success | Scott Barry Kaufman : 1261 1:14:46

9 days ago1:14:46

1:14:46

You hold the door open. You say yes when you mean no. You put others first—always. It feels like the right thing to do… but is it costing you more than you realize? In this episode, Scott Barry Kaufman, Ph.D.—Columbia professor, psychologist, and author of Rise Above—joins Dave Asprey to expose the psychology of victim vs. empowerment mindsets . He reveals how toxic altruism, external validation, and emotional fragility keep people stuck—and how you can reclaim your confidence, set boundaries, and create a life of true growth . Dr. Kaufman, one of the world’s most cited scientists , shares cutting-edge research on self-actualization, resilience, and the hidden mental loops that shape your success . If you’ve ever felt stuck in self-doubt, drained from over-giving, or afraid to take up space , this conversation will help you break free . What You’ll Discover in This Episode: • Victim vs. empowerment mindset —the key shift that changes everything • The psychological traps of toxic altruism —and why over-giving holds you back • How people-pleasing rewires your brain —and how to break the cycle • The science of self-actualization —how to unlock your full potential without guilt • Why modern culture and social media reward emotional fragility—and how to rise above it • The neuroscience behind confidence, resilience, and making better choices for YOUR growth If you’ve ever felt stuck, undervalued, or drained from always being “nice” , this episode will show you how to step into your power, rewrite your mental programming, and take control of your future. SPONSORS -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: • A Day of Biohacking and Consciousness Event: https://daveasprey.com/biohacking-and-consciousness/ • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Scott’s Instagram : https://www.instagram.com/scottbarrykaufman/?hl=en • Scott's New Book – Rise Above : https://scottbarrykaufman.com/books/rise-above/ • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:44 Intro • 02:02 Rise Above – Scott’s New Book • 03:13 Triggers and Mind Control • 05:12 Victimhood and Self-Actualization • 12:01 Curiosity Over Fear • 16:32 The Power of Discernment • 26:32 Emotional Resilience Today • 31:12 The Fragility of Younger Generations • 37:33 Social Pressures and Identity • 39:47 Social Media and Self-Determination • 40:35 Community and Belonging • 42:42 Activating Happiness and Growth • 44:43 Gratitude and Daily Practices • 51:48 Healthy Selfishness vs. Altruism • 58:56 Codependency and Vulnerable Narcissism • 01:04:57 The Dark Triad and Personality Types • 01:09:14 Final Thoughts and Book Recs See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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MDMA Therapy Without the Drugs? How Vibration Hacks Your Brain for Neuroplasticity | Dave Rabin : 1260 58:25

13 days ago58:25

58:25

What do vibrations and the psychedelic experience have in common? MDMA therapy is revolutionizing mental health treatment, helping people overcome PTSD, anxiety, and emotional trauma with unprecedented success. But what if you could tap into those same powerful benefits—without taking a single drug? It turns out your brain responds to more than just chemistry. Vibration, frequency, and rhythm have been shaping human consciousness for millennia—from ancient chanting rituals to modern neuroscience breakthroughs. Could the right vibrations unlock the same neuroplasticity and healing pathways as psychedelics? In this episode, Dave Asprey sits down with Dr. Dave Rabin, a neuroscientist, psychiatrist, and psychedelic researcher, to explore how vibrations can rewire your brain, enhance neuroplasticity, and even mimic the effects of MDMA therapy. Dr. Rabin’s work led to the creation of Apollo Neuro, a wearable device that taps into your nervous system’s natural ability to regulate stress, boost focus, and accelerate recovery—without pharmaceuticals. What You’ll Discover in This Episode: • How specific vibrations trigger deep relaxation and neuroplasticity • Why MDMA therapy works—and how vibration-based tech can simulate it • The surprising science behind music, frequency, and altered states • How Apollo Neuro enhances sleep, focus, and emotional resilience • The overlooked role of heart rate variability in longevity and health • Why stress is the biggest obstacle to healing—and how to override it **Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%** Resources: • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Apollo Neuro Instagram : https://www.instagram.com/apolloneuro/?hl=en • Apollo Neuro Website : https://apolloneuro.com/Dave • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: 00:00 Trailer 00:40 Intro 01:18 Exploring Vibration in Biohacking 02:29 Introduction of Dr. Dave Rabin 02:53 Understanding Vibration and Its Impact 04:47 The Apollo Neuro Device 08:44 Using Apollo for Different States 11:41 Apollo in Psychedelic Therapy 24:32 Clinical Trials and Studies on Apollo 29:32 Heart Rate Variability and Biohacking 33:02 Revolutionizing Sleep with Apollo 34:40 Apollo’s Long-Term Effects and Dependency 37:16 Apollo’s Impact on ADHD and Psychiatric Disorders 45:22 The Importance of Human Connection and Simple Solutions 49:56 Longevity, Healthspan, and Future Innovations 57:23 Final Thoughts and Discount Offer See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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Brain Hacking 101: The Science of Self-Sabotage & Mind Reprogramming | Bizzie Gold : 1259 1:09:58

14 days ago1:09:58

1:09:58

Your Brain is Lying to You—Here’s How to Take Back Control Every day, your brain is running subconscious scripts—hidden mental loops that shape your decisions, habits, and even your self-worth. But what if those loops are sabotaging you? In this episode, Bizzie Gold , mind architect and creator of The Break Method , joins Dave Asprey to expose the self-deception patterns controlling your thoughts —and how to reprogram your brain for true transformation . Bizzie’s method isn’t just another self-help philosophy. It’s science-backed , no BS , and engineered for results . From subconscious conditioning to emotional addiction cycles, you’ll learn the exact framework for breaking free from limiting beliefs and upgrading your mind. What You’ll Discover in This Episode: • The hidden mental loops sabotaging your success (and how to break them) • The science of self-deception —why your brain lies to you daily • How early childhood experiences hardwire your thoughts and emotions • The brain’s rejection vs. abandonment patterns —which one rules you • How to use E.L.I. questions to disrupt negative thinking instantly • The AI-powered brain upgrade that could change self-improvement forever If you’ve ever felt stuck in repetitive thought patterns, bad habits, or emotional cycles , this episode will give you the blueprint to take back control of your mind . Listen now—because your brain won’t fix itself. SPONSORS -Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Bizzie Gold’s Instagram : https://www.instagram.com/bizziegold/ • Bizzie Gold's Website : https://bizziegold.com/ • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 00:28 – Intro • 01:39 – Understanding self-deception and its impact • 05:41 – The role of childhood trauma in shaping perception • 14:20 – Brain pattern spectrum and human behavior • 22:26 – Spiritual perspectives on DNA and past lives • 34:45 – Sharing knowledge from the ether • 34:54 – A surprising encounter with a professor • 35:43 – Healing and accessing intuition • 36:39 – The power of intuition in practice • 38:15 – Spiritual technology and Big Pharma • 39:54 – The role of self-trust in intuition • 40:49 – Understanding instinct vs. intuition • 42:17 – The E.L.I. framework for intuition • 45:50 – Hacking the brain’s language system • 57:04 – Parenting for emotional resilience • 01:06:13 – AI and emotional hacking • 01:11:01 – Conclusion and final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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How Learning a New Language Rewires Your Brain—Lessons from the Pirahã Tribe | Daniel Everett : 1258 1:11:50

16 days ago1:11:50

1:11:50

Is the Way You Speak Limiting How You Think? For years, scientists debated how language shapes the brain, but new research reveals it goes far beyond communication. Some languages lack numbers, grammar, or even complex sentences—yet their speakers navigate reality in ways that defy expectations. In this mind-bending episode, linguist Daniel Everett, known for challenging Noam Chomsky’s theories, shares how his time with the Pirahã people reshaped our understanding of language, cognition, and even consciousness. If language rewires thought, what happens when AI starts using it? Can a machine truly think? And what if whales, with their massive brains, have a language of their own? What You’ll Discover in This Episode: • The hidden power of language—why learning a new one literally reshapes your brain • The Piraha people’s mind-blowing approach to communication and what it reveals about human thought • Can AI truly “think” in language, or is it just an advanced mimic? • How your environment affects memory, navigation, and cognitive function • The psychedelic connection to language evolution—could altered states have unlocked speech? SPONSORS • Puori | Visit https://puori.com/dave and use code DAVE for 20% off. • BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dan Everett’s Website: https://daneverettbooks.com/ • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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Your Genes AREN’T Your Fate—The NEW Science of DNA Biohacking for SuperHuman Health | Sharon Hausman-Cohen : 1257 1:18:33

20 days ago1:18:33

1:18:33

For decades, we’ve been told that our DNA is a fixed blueprint—an unchangeable code that dictates our health and lifespan. But what if that’s only half the story? Sharon Hausman-Cohen, a physician, researcher, and genomics expert at IntellxxDNA, joins Dave to reveal the cutting-edge science of genetic optimization —how understanding your DNA can unlock longer life, better brain function, and even protection from chronic disease. Forget the old-school genetic reports that left you with useless percentages. The new frontier of precision genomics goes beyond risk factors to actionable insights , showing you exactly how to turn on your body’s most powerful longevity genes and turn off the pathways driving inflammation, cognitive decline, and disease. What You’ll Learn in This Episode: • Why genetics alone don’t determine your future —and how to use epigenetics to control your health • The truth about MTHFR, APOE4, and other “bad” genes —are they actually harming you? • How genetic reports can predict and eliminate brain fog, fatigue, and pain • The hidden genetic reasons behind ADHD, depression, and anxiety —and how to fix them • Why some people age faster —and the one longevity gene that determines your biological age • Cutting-edge breakthroughs in DNA-based biohacking —is it possible to edit your genes for peak performance? This is the future of personalized medicine. By understanding your own genetic blueprint, you can stop guessing and start making the precise changes that will optimize your energy, brainpower, and lifespan! ** Visit IntellxxDNA at https://intellxxdna.com/asprey/ When you go to the website to find a clinician please select “human upgrade/longevity” as the type of consult to get specialized biohacking clinicians! ** SPONSORS -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Resources: • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • IntellxxDNA Website : https://intellxxdna.com/asprey/ • 2025 Biohacking Conference : https://biohackingconference.com/2025 • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: • 00:00 – Intro • 02:00 – The Role of Genetics in Longevity • 03:37 – Gene Variants & Cognitive Health • 05:58 – Epigenetics vs. Genetics • 08:21 – Genomics & Pain Management • 09:26 – Breakthroughs in Genetic Research • 12:33 – The Future of Genomic Medicine • 14:27 – How to Use Genomic Reports • 38:25 – Mitochondria & Longevity • 42:40 – BH4 & Mental Health • 43:42 – Folinic Acid & Brain Function • 44:37 – Genomics & Autism • 46:06 – Personalized Medicine • 56:00 – APOE4 & Alzheimer’s Risk • 59:44 – Genetics & Heart Health • 01:04:54 – The Future of Precision Medicine • 01:20:23 – Conclusion & Next Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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How to Build New Habits and KEEP Them! BJ Fogg & James Clear : 1256 27:39

22 days ago27:39

27:39

For years, we’ve been told that willpower and repetition are the keys to forming habits. But the truth is, habits don’t stick because of repetition—they stick because of emotion! In this all-time classic episode, Dave brings together two of the world’s top habit experts—BJ Fogg, PhD, and James Clear—to break down the real science of behavior change. BJ, the Stanford researcher behind Tiny Habits , explains why motivation, ability, and the right prompts are the real drivers of habits. Meanwhile, Atomic Habits author James Clear reveals how small decisions compound over time to shape your entire life. What You’ll Learn in This Episode: • Why willpower and repetition don’t work —and what actually makes habits stick • The tiny changes that create massive, lasting results • How emotions play a bigger role in habit formation than you think • The hidden power of stacking small habits for exponential growth • How to automate your decisions to free up brainpower for bigger goals SPONSORS -STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order. -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE . Resources: • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • BJ Fogg’s Website – https://www.bjfogg.com/ • James Clear’s Website : https://jamesclear.com/ • 2025 Biohacking Conference : https://biohackingconference.com/2025 • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:39 – Understanding habits • 01:10 – Layering habits with James Clear • 01:49 – BJ Fogg’s Tiny Habits method • 03:03 – The science of habit formation • 05:49 – Practical habit-building tips • 09:57 – Emotions vs. repetition in habits • 18:02 – Ability & context in habits • 21:19 – Genes, dopamine & behavior • 26:20 – Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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Hacking Oxytocin, How to Use Rapamycin, Level Up Your At-Home Cold Plunge, Curing Asperger’s & More! AMA #1 with Dave Asprey : 1255 55:28

28 days ago55:28

55:28

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective ! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life! In today’s episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger’s traits through neuroplasticity and mitochondrial upgrades. There’s even some great advice for all the parents out there! What You’ll Learn: • How to naturally boost oxytocin for better relationships and emotional health • The fastest way to upgrade your cold plunge for heat shock benefits • Is rapamycin really a longevity miracle? Dave’s personal take • How mitochondria impact brain power, mood, and aging —and how to fix them today! • The shocking reason some people can’t process reality correctly (and how to retrain your brain) • The real truth about stem cells, exosomes, and V-cells for regeneration • The hidden dangers of selenium, thyroid supplements, and over-fasting SPONSORS -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Upgrade Collective Membership : https://www.ourupgradecollective.com • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • 2025 Biohacking Conference : https://biohackingconference.com/2025 • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:37 – Welcome to the Human Upgrade AMA • 01:13 – Cold Plunges and Alpha Lipoic Acid for Health • 03:11 – Hot and Cold Therapy for Optimal Health • 07:29 – Understanding Thyroid Health and Treatment • 09:09 – The Importance of Selenium • 14:41 – Stem Cells vs. Exosomes • 16:27 – Rapamycin for Longevity • 18:07 – Asperger’s Syndrome and Neuroinflammation • 28:53 – Understanding Asperger’s and Self-Awareness • 29:24 – The Challenge of Offering Help • 30:06 – The Importance of Reconnection Work • 31:34 – Personal Development Journey • 34:42 – The Role of Emotions in Biohacking • 35:55 – Dealing with Flashbacks and Trauma • 45:46 – The Power of Oxytocin • 49:48 – The Truth About Kale and Oxalates • 54:25 – Teaching Kids to Regulate Their Nervous System See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

1
The New Fasting Protocol to Increase Lifespan by 96% | Chris Rhodes : 1254 1:06:55

30 days ago1:06:55

1:06:55

Can You Mimic Fasting—Without Actually Fasting? Chris Rhodes, a biochemist and longevity researcher, joins Dave to reveal a groundbreaking fasting mimetic that could revolutionize how we approach aging, metabolism, and health. Fasting is one of the most powerful tools for longevity, but what if you could achieve the same benefits without hunger, energy crashes, or social sacrifices? Scientists have identified key compounds that mimic fasting at the cellular level—offering a way to extend lifespan, boost metabolism, and enhance cognitive function without giving up food. Enter Mimio, a blend of four key molecules naturally produced during fasting, is engineered to deliver the life-extending benefits of fasting—without starvation. For decades, fasting has been the gold standard for longevity, but over-fasting can wreck hormones, metabolism, and muscle mass. So, what if you could get the benefits of a 36-hour fast without the downsides? Chris breaks down the science behind fasting, autophagy, and the game-changing compounds that trick your body into entering a fasted state— even while eating. What You’ll Learn: • The optimal fasting window for maximizing lifespan (Hint: It’s not 16 hours) • The four fasting metabolites that extend life by 96% • How Mimio mimics fasting benefits—without giving up food • The real reason over-fasting destroys your metabolism and hormones • Why traditional longevity drugs (Metformin, Rapamycin) fall short • Can you build muscle and burn fat at the same time? The science of mTOR & AMPK • Why Big Pharma doesn’t want you to know about this breakthrough *** Get 20% off Mimio at mimiohealth.sjv.io/3J9abX with code: DAVE *** Sponsors: Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Mimio Instagram: https://www.instagram.com/mimiohealth/ • Mimio Website : https://mimiohealth.com/ • 2025 Biohacking Conference : https://biohackingconference.com/2025 • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: • 00:00 – Intro • 00:58 – Fasting & Longevity • 01:88 – Optimal Fasting Length • 03:39 – Alternate Day Fasting: Pros & Cons • 05:50 – Key Fasting Compounds • 07:34 – Spermidine & Longevity Molecules • 11:41 – FDA Roadblocks on Natural Compounds • 15:37 – AI, Big Data & Longevity Research • 31:19 – Mimio’s Impact on Testosterone & Aging • 35:16 – Longevity & Death Philosophy • 36:48 – Biohacking Origins • 37:03 – Metabolism & Cognitive Function • 38:35 – Unexpected Effects of Fasting • 40:43 – Fasting & Circadian Rhythms • 43:09 – Mimio Science & Benefits • 45:14 – Mimio in a Daily Routine • 55:05 – Men vs. Women: Fasting Differences • 01:02:23 – Future of Nutrition & Biohacking • 01:07:21 – Conclusion & Discount Code See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

1
The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253 1:24:01

5 weeks ago1:24:01

1:24:01

Could a single molecule be the difference between vibrant longevity and early decline? Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD. This master molecule fuels your mitochondria, DNA repair, and cellular resilience , but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it? Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair —and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity. Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer. What You’ll Learn: • The #1 reason your NAD is disappearing—and how to fix it • Why NAD is the missing link in energy, DNA repair, and disease prevention • The hidden enzyme (CD38) that’s sabotaging your longevity • How to supercharge mitochondria, optimize blood flow, and fight aging at the source • Why the supplement industry has it wrong—and the best way to boost NAD naturally • The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine Resources: • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Wonderfeel Instagram – https://www.instagram.com/getwonderfeel/ • Wonderfeel Supplement : https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast • 2025 Biohacking Conference : https://biohackingconference.com/2025 • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com Timestamps: 00:00 Trailer 01:07 Introduction and Episode Overview 02:29 Meet Dr. Andrew Salzman 02:36 From Physician to Researcher 03:39 Pharmaceuticals vs. Nutritionals 04:17 The Role of NAD in Longevity 06:32 Challenges in Longevity Research 12:58 Understanding NAD and PARP 14:34 NAD’s Impact on Health 23:19 Gut Health and Longevity 27:43 Innovations in NAD Supplementation 41:27 Customer Feedback and Product Effectiveness 42:41 Surprising Benefits of NAD for Sexual Health 44:47 NAD and Vascular Health 48:46 NAD’s Role in Aging and Longevity 54:03 NAD and Lifestyle Choices 01:03:02 NAD and Cognitive Function 01:06:18 NAD and Exercise 01:13:42 NAD and Sleep 01:21:54 Final Thoughts on NAD and Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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Fix Your Blood Sugar: The FASTEST Way to Burn Fat, Optimize Hormones & Reverse Disease | Benjamin Bikman : 1252 1:20:08

5 weeks ago1:20:08

1:20:08

Welcome to the metabolism masterclass! Dr. Ben Bikman (Ph.D Professor BYU), a powerhouse in metabolism science, joins Dave to expose the truth about insulin resistance —the silent epidemic fueling obesity, chronic disease, and low energy. Forget the outdated calorie-counting nonsense (it doesn’t work)—Dr. Bikman reveals how your hormones, not just your diet, control your metabolism and what you can do to reset it fast. From debunking diet myths to uncovering why some people can eat 400 grams of carbs and never gain fat (hint: it’s not what you think), this episode unpacks the real science of fat storage, energy, and optimal health. Get ready for mind-blowing insights, metabolic hacks, and a new way to think about food, fasting, and longevity. What You’ll Learn: • The #1 driver of insulin resistance—and why most doctors miss it • Why eating more fat (yes, really) could be the key to reversing metabolic dysfunction • How fasting, cold therapy, and red light impact your metabolism • The truth about carbs, seed oils, and why some people can’t gain fat • How to tell if insulin resistance is wrecking your energy & health Resources: • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Benjamin’s new book How Not To Get Sick : https://a.co/d/aADlMWv • Benjamin’s YouTube Page – https://www.youtube.com/@benbikman • 2025 Biohacking Conference : https://biohackingconference.com/2025 • Danger Coffee : https://dangercoffee.com • Dave Asprey’s Website : https://daveasprey.com • Dave Asprey’s Linktree : https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live : https://www.ourupgradecollective.com • Own an Upgrade Labs : https://ownanupgradelabs.com • Upgrade Labs : https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement : https://40yearsofzen.com SPONSORS: -Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: 00:00 Trailer 00:52 Introduction to Dr. Benjamin Bikman 02:20 The Battle Against Conventional Dietetics 04:12 Understanding Insulin Resistance 06:29 The Two Paths to Insulin Resistance 10:19 Fasting and Metabolic Health 14:11 Insulin and Cognitive Enhancement 18:16 Identifying Insulin Resistance 30:12 The Role of Insulin in Fat Storage 42:04 Understanding Glucose and Insulin Dynamics 42:26 The Role of Exercise in Glucose Regulation 42:54 AMPK and Muscle Contraction 45:21 Calories In, Calories Out Debate 46:15 The Myth of Calorie Counting 50:13 Ketosis and Metabolic Rate 51:14 Intermittent Fasting and Muscle Preservation 55:21 Insulin Resistance and Ketogenic Diets 01:02:04 Circadian Rhythm and Insulin Sensitivity 01:08:08 Environmental Toxins and Insulin Resistance 01:13:03 The Impact of Seed Oils on Insulin Resistance 01:19:22 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

1
Rick Rubin: How to Hack Your Mind for Creative Breakthroughs : 1251 54:51

5 weeks ago54:51

54:51

Most people wait for inspiration. But what if you could train your brain to create on demand? Rick Rubin has spent decades shaping the sound of legendary artists—Jay-Z, Johnny Cash, Metallica, and countless others—by tapping into the unseen forces of creativity. But what’s the secret behind his genius? In this must-listen episode, Rick sits down with Dave to explore the science and soul of creativity , revealing how meditation, mindfulness, biohacking, and unconventional thinking fuel artistic breakthroughs. From rewiring your brain with meditation to stacking biohacks for peak creative flow, Rick shares the techniques that have kept him at the top of the music industry for over 40 years. Dave and Rick go deep on the mental and physiological hacks that enhance creative performance , the surprising link between biohacking and artistry, and the rituals that keep Rick sharp, focused, and endlessly inspired. What You’ll Learn: • How Rick Rubin taps into creative flow—and how you can too • The surprising connection between meditation and peak artistic performance • Why biohacking isn’t just for longevity—it’s for creative mastery • Rick’s favorite tools for mental clarity, focus, and creative breakthroughs • The real secret behind working with the world’s biggest artists • How to cultivate an environment that fuels creativity Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Rick’s New Book The Creative Act: A way of Being: https://a.co/d/2bLbjeS • Rick’s Instagram: https://www.instagram.com/rickrubin/?hl=en • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Timestamps: • 00:00 – Trailer • 00:51 – Intro to Rick Rubin • 02:51 – Rick’s Musical Journey • 03:06 – The Creative Process • 08:31 – Biohacking & Sensitivity • 13:46 – Meditation & Creativity • 19:37 – Rick’s Weight Loss Story • 29:21 – Eating Habits & Rhythm • 29:55 – Advanced Biohacking • 31:23 – Oxygen Therapy & Carbogen • 35:16 – Peptides & Longevity • 45:59 – Prayer, Gratitude & Performance • 51:03 – Reflections on Life & Mortality See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

1
Tony Robbins on the Ultimate Secrets to Wealth, Mindset, and Success : 1250 56:49

6 weeks ago56:49

56:49

What’s keeping you stuck in a scarcity mindset instead of stepping into abundance? What truly sets successful people apart from those who struggle? Tony Robbins has spent decades answering these questions—coaching billionaires, world leaders, elite athletes, and everyday people to master their money, mindset, and mission. In this all-time classic podcast, he shares the hard-hitting truths about financial freedom, why fear is your biggest enemy, and how to break free from the psychological traps that keep you stuck. Tony and Dave dive deep into the wealth-building playbook that the world’s top investors use (including Warren Buffett, Ray Dalio, and Paul Tudor Jones), plus the biohacks and routines that fuel Tony’s legendary stamina. From the real secret to compounding wealth to stem cell breakthroughs that could change human longevity , this episode will shift the way you think about money, health, and success. Most people dream of financial freedom, but few actually achieve it. What’s holding you back—and how can you break through? What You’ll Learn: • The biggest mistake people make with money (and how to avoid it) • The mindset of the ultra-wealthy —how top investors think differently • Why fear is your greatest enemy in investing and personal success • The three essential money buckets —security, growth, and dreams • Tony’s top biohacks for insane energy and peak performance • The real secret to happiness and fulfillment (it’s not what you think) Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Tony’s Website: https://www.tonyrobbins.com/ • Tony’s Instagram: https://www.instagram.com/tonyrobbins/?hl=en • Dave Asprey’s New Book - Heavily Meditated : https://daveasprey.com/heavily-meditated/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Puori | Visit https://puori.com/dave and use code DAVE for 20% storewide. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Timestamps: • 00:00 Intro • 00:50 Meet Tony Robbins • 02:18 Financial Wisdom & Motivation • 05:43 Psychology of Wealth • 10:10 Investment Strategies • 15:24 Balancing Money & Experiences • 21:21 Power of Giving • 30:06 Paying for College • 31:00 Commitment & Success • 31:53 Energy & Biohacks • 35:12 Cryotherapy & Inflammation • 38:54 Stem Cells & Regeneration • 41:59 Financial Freedom • 46:35 Wnt Pathway Breakthroughs • 52:35 Health & Longevity • 56:34 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info .…

The Human Upgrade with Dave Asprey

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Timbaland's Blueprint: How to Lose 130 Pounds, Beat Addiction, and Change Your Life TODAY! : 1249 40:01

6 weeks ago40:01