Robert Langer has co-founded dozens of companies, holds over a thousand patents, and is a pioneering figure in drug delivery... more

Mateo Jaramillo is the co-founder and CEO of Form Energy. Mateo’s problem is this: How do you build batteries that... more

This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is... more

Imagine picking up your phone and ordering something from Walmart. Fifteen minutes later, a drone hovers over your yard, lowers... more

Psychedelics are going mainstream. The FDA has approved ketamine for certain patients with depression, and may soon approve MDMA for... more

Kai Marshland is the co-founder and chief product officer at WindBorne Systems. Kai's problem is this: How do you build... more

Jonathan Hurst is a professor at Oregon State University, and co-founder and chief robot officer at Agility Robotics. Jonathan's problem... more

The 2008 Global Financial Crisis was hard for almost everyone. Fuquan Bilal remembers it like it was yesterday. A real... more

What does sickness sound like? Sometimes it’s obvious, like a cough, sniffle, or stuffy nose. But some conditions cause subtle... more

Cement is, almost literally, everywhere. It is extraordinarily useful, which is why humanity makes 4 billion metric tons of it... more

Sam D'Amico is the founder and CEO of Impulse Labs, a company that makes induction stoves, with a clever twist.... more

Tim Ellis is the co-founder and CEO of Relativity Space, a company with a unique approach to manufacturing rockets. Tim’s... more

Every year in the U.S., tens of thousands of hospital patients die of preventable causes. For many of these patients,... more

Gia Schneider is the co-founder and CEO of Natel Energy, a company that is trying to transform the way hydroelectric... more

Peter Chen is the co-founder and CEO of Covariant. Peter’s problem is this: How do you take the AI breakthroughs... more

Fei-Fei Li is a Stanford computer scientist and the former chief scientist of artificial intelligence/machine learning at Google Cloud. When... more

Tim Latimer is the CEO and co-founder of Fervo Energy, a company that is using a new approach to produce... more

Manolis Kellis is a professor of Computer Science at the Massachusetts Institute of Technology. He works in computational biology, taking... more

After working as a chef for decades, Anthony Strong’s dream came true: He opened his own restaurant. His problem was... more

Selling hydrogen to make fertilizer is a huge business. It also drives tons of carbon emissions. Rob Hanson, the co-founder... more

Frances Frei and Anne Morriss are the co-founders of a training and consulting company called The Leadership Consortium. Together they... more

When a Dutch crime reporter makes an unbelievable discovery, a small-town murder case begins to look like an international assassination... more

A few weeks ago, Jacob Goldstein sat down with a writer and a composer on a stage in Chicago to... more

Jigar Shah is the director of the Loan Programs Office at the U.S. Department of Energy. Last year, as part... more

Pushmeet Kohli is vice president of research at DeepMind, an AI research group that is part of Google. Every protein has... more

Forrest Meyen is the co-founder and Chief Strategy Officer of Lunar Outpost, a company that builds machines that go to... more

Brannin McBee is the co-founder and Chief Strategy Officer at CoreWeave. A few years ago, he and a few friends started... more

Sam Bankman-Fried, the former crypto mogul, is on trial for fraud. On today’s show, we talk to Lidia Jean Kott,... more

Christina Smolke is the co-founder and CEO of Antheia. Antheia is a synthetic biology company -- they’re in the business... more

Stephen Klein is the co-founder and CEO of Hyphen, a company that is developing an automated make line. Stephen's problem... more

Simon Johnson is an MIT economist and the co-author of a new book called “Power and Progress: Our Thousand-Year Struggle... more

Sal Khan is the founder and CEO of Khan Academy. Sal’s problem is this: How do you design an AI... more

What can we learn from the centuries-long quest to eradicate smallpox, once the scourge of humanity? And how did it... more

Allon Bloch is the co-founder and CEO of K Health. Allon’s problem is this: Can you use AI to make... more

Sonia Kastner is the founder and CEO of Pano. Sonia’s problem is this: How do you use data and machine... more

Amit Sharma is the founder and CEO of Narvar. Narvar works with companies such as Sephora, Lululemon and Home Depot to... more

Danielle Feinberg is a Visual Effects Supervisor at Pixar Animation Studios. Danielle’s problem is this: How do you optimize technology... more

Yaron Singer is the founder and CEO of Robust Intelligence. Yaron’s problem is this: How do you reduce AI’s security... more

Chris Monroe is the co-founder and chief scientist of IonQ. Chris’s problem is this: How do you build a quantum... more

Seven stocks are powering the market: Alphabet, Amazon, Apple, Meta, Microsoft, Nvidia and Tesla. How will they do in the... more

Charles Fisher is the co-founder and CEO of Unlearn AI. Charles’ problem is this: How do you build an AI... more

Laura Modi is the founder and CEO of Bobbie, a company that makes baby formula and sells it directly to... more

Xiao Wang is the founder of a company called Boundless. Xiao’s problem is this: How do you make it cheaper... more

Henrik Stiesdal got his start in wind power back in the 70s. The price of oil had gone way up,... more

One of the most amazing things about ChatGPT and other, similar AI models: Nobody really understands what they can do.... more

Dan Friedmann is the CEO of Carbon Engineering. The company is at the frontier of a new industry, direct air... more

Does flying have to be bad for the environment? Val Miftakhov, the founder and CEO of ZeroAvia, doesn’t think so.... more

Andrew Mason is the founder and CEO of Descript. Descript's software has made editing audio and video much simpler.  The company... more

Andrew Ponec is co-founder and CEO of the energy storage company Antora Energy.  Andrew's problem is this: How can you store... more

Tammy Hsu and Michelle Zhu are the cofounders of Huue.  Their problem is this: how do you get bacteria to produce... more

Today's show is about a problem people have been trying to solve for a hundred years: how can we mass... more

Alexis Rivas is the co-founder and CEO of Cover. His problem is: How do you build houses in a factory, the... more

Nina Tandon is the co-founder and CEO of a tissue engineering company called EpiBone. Her problem is this: How do you grow... more

Microchips are the most important driver of technological progress in the modern world, and governments are fighting over who gets... more

It's our first anniversary and—almost 50 episodes in—Jacob Goldstein checks in with three past guests. Drone delivery guy Keenan Wyrobek thinks... more

Alice Zhang is the co-founder and CEO of Verge Genomics. Alice's problem is this: How do you use artificial intelligence... more

When Austin Russell was 17 years old, he founded Luminar Technologies to work on a remote sensing technology called Lidar.  Today,... more

Chace Barber is the co-founder of Edison Motors. Chace's problem is this: How do you build electric logging trucks in... more

Here's a bonus episode of a new show from Pushkin, Other People's Pockets. Have you ever wondered how your friend bought... more

Caspar Coppetti is the co-founder of On, a company that makes athletic shoes. Caspar's problem is this: How can you... more

After a historic 355 days in orbit, NASA astronaut Mark Vande Hei returned to Earth on March 30, 2022, breaking... more

Matt Rogers is the co-founder of Mill. Matt's problem is this: How do you turn garbage into food?Before Mill, Matt co-founded... more

Jacob Goldstein co-hosts today's show with Dan Pashman, host of The Sporkful. Jacob and Dan eat their way through the... more

Pat Brown is the founder of Impossible Foods. Pat's problem is this: How can you make meat without animals? Pat's goal... more

Ilir Sela is the co-founder and CEO of Slice. His problem: How do you bring the technological revolution to thousands... more

Tim Mundon is chief technology officer at Oscilla Power. Tim's problem is this: How do you turn waves into electrical... more

While we’re off celebrating the new year, here’s an episode from another Pushkin show: Some of My Best Friends Are… Hosts... more

Anders Forslund is the co-founder and CEO of Heart Aerospace. Anders' problem is this: How do you build a commercial... more

Bayard Winthrop is the founder and CEO of American Giant. Bayard's problem is this: How do you make clothes in America -- and... more

Farzad Mostashari is the co-founder and CEO of Aledade. Farzad's problem is this: How can we pay doctors to keep... more

This bonus episode is from Story of the Week with Joel Stein, a new Pushkin podcast. On Story of the... more

Sallie Krawcheck is the founder and CEO of Ellevest, an investment firm for women that has over $1 billion in... more

In May of this year, we interviewed Sam Bankman-Fried, the young billionaire philanthropist who started the crypto exchange FTX. Last week,... more

Stacey Vanek Smith is the author of "Machiavelli for Women: Defend Your Worth, Grow Your Ambition, and Win the Workplace."... more

Cathy Edwards is vice president and GM of Search at Google. Cathy's problem is this: how do you teach computers... more

Matt Duesterberg is co-founder and president of OhmConnect. Matt's problem: How do you build a business around getting people to... more

Chris Best is co-founder and CEO of Substack. Chris's problem: How do you help writers make a living from a thousand... more

Harley Finkelstein is the president of Shopify. He may love entrepreneurship more than anyone we've ever met. Harley’s problem: How do... more

Shaun Kinetic is co-founder and chief scientist of Charm Industrial. Shaun’s problem: How do you put billions of tons of... more

Al Doan is the executive chairman of the Missouri Star Quilt company. Al's problem is this: How do you combine low... more

Chris Severn is the co-founder and CEO of Turquoise Health. Chris's problem is this: How do you figure out the real... more

Mariana Matus is co-founder and CEO of Biobot Analytics. Her problem: How do you turn sewage into useful public health... more

Matt Mullenweg co-created WordPress, the open-source software that powers more than 40% of all the websites in the world. He's also... more

Mohammed Ashour is the co-founder and CEO of Aspire Food Group. The company just built the biggest cricket factory in... more

We put man on the moon before we invented the wheeled suitcase. Why did it take so long? Find out in... more

Rajiv Maheswaran is the co-founder and president of Second Spectrum. Rajiv and his company figured out how to turn raw... more

David Neeleman has founded five airlines, including JetBlue. He recently launched a new airline, called Breeze. His problem: How do you... more

Bill Shufelt is the founder and CEO of Athletic Brewing Company. His problem: How do you turn non-alcoholic beer from a... more

John Green is the author of The Fault in Our Stars and six other novels. He also co-founded a company... more

Luana Lopes Lara is the co-founder of Kalshi, an exchange that lets ordinary people bet on everything from the path... more