Depresh Mode with John Moe

Cameron Esposito has many titles: hugely successful standup comedian, actor in television and film, writer, podcast host. After a recent rehab stay led to a mental health diagnosis, she has realized that she’s also a person with bipolar disorder, type II. Cameron has a new special, Four Pills, that’s part stand-up comedy and part reflection on the circumstances that led to this discovery as well as thoughts on what life as a treate...

Statistics say that 23% of Americans are currently living with some form of mental illness. For most people, that calls for reaching out for help and receiving treatment and advice on management. But if you’re an FAA-approved airline pilot, disclosing that you have something like a depressive disorder or an anxiety problem can mean a temporary pause or permanent end to your entire career. Of course, having a mental illness, not dis...

Hanif Abdurraqib is a MacArthur Fellow, accomplished poet, and critically lauded author of numerous books, including There’s Always This Year: On Basketball and Ascension, which is now out in paperback. He’s also a person who deals with major depressive disorder and numerous anxiety disorders. In a revealing, positive, and practical interview, Hanif talks about the numerous ways he cares for his mental health issues by both taking ...

Things are scary in this country these days for a lot of people. There is turmoil in the government, shakiness in the economy, and a deep divide over what America even means anymore. In times of upheaval, it’s a good idea to reach out to friends, see how they’re holding up, help carry their burdens and sorrows, and see what wise advice they can share about perseverance. We do this on our show from time to time. In this mini-episode...

We’ve been seeing an influx of new listeners recently. It’s very exciting. Thank you for that and we’re delighted that you’ve joined us. So we thought we’d take a moment and explain what the show is all about and who it’s for. Spoiler alert: it’s for everyone, including you, regardless of your mental health history.

It's the final week of the 2025 Max Fun Drive! Check out the fun thank you gifts and become a member of Max Fun!

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“I’m very kind to Jim, I’m trying to take good care of Jim, I’m trying to love Jim,” says musician Jim James of the band My Morning Jacket. The kindness he’s showing Jim, himself, is a relatively new thing, he says, after a long time spent kind of beating up on the guy. As My Morning Jacket releases its new album, is, Jim reflects back on issues such as a need for validation through achievement, alcoholism, and depression. And he s...

In this bonus content edition of Depresh Mode, We’re joined by some Maximum Fun all-stars for some very light-hearted and delightfully competitive games that are as informative as they are silly.
 

Our competitors:

• Justin McElroy of My Brother, My Brother, and Me, Adventure Zone, and Sawbones
• Hal Lublin of Tights & Fights and We Got This
• Laura Swisher, senior producer overseeing about a million Max Fun podcasts

Who will win the ...

It’s not MaxFunDrive without a wild kickoff spectacular! Former real-life VJ and host of MTV's Spring Break 1999, Dave Holmes, takes your favorite MaxFun hosts through some wacky ‘90s- and Spring Break-themed mini games!!

Featuring: Dave Holmes, Jeremy Bent, Oscar Montoya, Dimitry Pompée, Tom Lum, Ellen Weatherford, Alex Schmidt, Brenda Snell, Drea Clark, Alonso Duralde, Dan McCoy, Jordan Morris, Manolo Moreno, Ella Hubber, Caroline...

The alcohol, says J. Kenji Lopez-Alt, came about in young adulthood, when it solved persistent social anxiety and made him the life of the party. As Kenji found tremendous success in food writing and restaurateuring, he found that he couldn’t really make it through the day without downing between two and five drinks. This wasn’t hard to pull off in the food business, surrounded by booze and a culture that heartily encouraged its co...

Maybe you’re one of those people who dreads even looking at the news these days, with stories of layoffs, tariffs, upheaval in foreign policy, and a lack of knowledge as to where this is all going and what it might mean for the future of America and the world. It’s a tumultuous time. When things are chaotic, it can be good to check in with one’s friends and that’s what Depresh Mode does this week. We have conversations of commisera...

Lamb of God is a very popular heavy metal band with Grammy nominations, gold records, and a huge headbanging following. Randy Blythe, front man for the band and author of a new book, Just Beyond the Light, is in recovery from drugs and alcohol and tells stories of finding sobriety, including how it was pretty easy to stay sober while on an Australian vacation surrounded by koalas but a lot harder once he returned to the States and ...

Microdosing involves taking very small amounts of psychedelic substances such as LSD or psilocybin, maybe seven to twelve percent of a regular dose. It’s not enough to “trip out” but enough, proponents say, to yield very positive results, especially in terms of treating depression that hasn’t responded well to other methods. The catalog of extensive clinical, scientific trials about the practice of microdosing is pretty limited but...

Ophira Eisenberg once believed that everyone had a trauma quota, a maximum amount of hardship that a person would face in life and once that mark was hit, nothing bad would ever happen again. It was a way of comforting herself after a car accident at age eight that seriously injured Ophira and killed her friend. Turns out that’s not how life works and Ophira still had cancer and a miscarriage to deal with later on. Ophira joins us ...

Would you get a device the size of a Nilla wafer implanted in your body if it meant relief from treatment-resistant depression? There are big advances being made in vagal nerve stimulation therapy, a process by which electrical impulses are fed into a patient’s vagus nerve to alleviate depression that hasn’t responded to more common treatments. We take a look at the science, the breakthroughs, and why your insurance might be more l...

The cover of Neko Case’s memoir features a young Neko in a swimsuit she says she wore for six months straight and she’s accompanied by a drawing of a big spiky-toothed monster who she says is there to protect her. The invention of such monsters can feel necessary when one’s parents are unavailable, simply not physically present, or, in the case of her mother, faking their own death only to reappear a year and a half later. Neko tal...

Sex is not always an easy topic to discuss. Issues like how to get what you want, how to make sure your partner is getting what they want, these are delicate conversations and often intimidating ones as well. Add in issues like depression and anxiety for one or more of the people involved and it becomes more complex still. Fortunately, we have Dr. Emily Nagoski with us who is an expert on sex and how to talk about it. She’s the aut...

Hari Kondabolu has never been afraid to talk about sensitive topics on stage. The veteran comedian, who has appeared on Conan, Kimmel, Letterman, and NPR’s Wait Wait... Don’t Tell Me mined material about race, immigration, and other societal hot button issues. But unlike some comedians, he was hesitant to discuss himself and in particular the depression that has followed him for years. He goes there in this interview that also incl...

On the podcast Hyperfixed, host Alex Goldman sets out to solve mysteries and conundrums that listeners submit. But he’s found himself having to do some figuring out for himself. Alex finally got diagnosed with ADHD just a few years ago, when he was around 42 years old. Which was a big relief after years of struggling with things like attention and task completion. The problem was that the meds they gave him triggered hypomania foll...

There are sad movies that nonetheless offer some sort of hope and optimism. And then there are the ones that offer no hope at all, just bleakness and despair and the cinematic versions of major depressive disorder. Those are our focus on this episode as a trio of film critics and pundits offer their picks for the most depressing films and offer analysis on whether there is value in watching works that present worlds with zero hope....