SKRAPS of Science & Innovation SKRAPS Studio

This is conclusion of the mini-series!
In this episode, we uncover the question, is the "cholinergic anti-inflammatory reflex" nerves entirely vagal? The answer is not so straightforward. Building on good work by Davide Martelli and Robin McAllen, we uncover crucial role of the efferent arm of the reflex to "also" be sympathetic.
And at the end, we also talk about the importance of understanding the referral and implantation pathway and why we remain muted in the ability of neuromodulation for immune-inflammation to be uptaken widely anytime soon.
SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.
Show Credits
Created & Produced by: Arun Sridhar Editing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam
Social Media:
Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter Feed
You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

With the set up of how vagus signalling was deduced by careful and meticulous experiments of Linda Watkins, who built on some amazing results from Hugo Besedovsky, we turn our attention to how the hypothesis moved from tackling acute inflammatory models (e.g. Sepsis) to chronic inflammatory models and disease conditions like Rheumatoid Arthritis.
We are joined by Tony Arnold, ex-CEO of SetPoint Medical and Dr. Paul-Peter Tak who pioneered the clinical trials in Rheumatoid Arthritis and Inflammatory Bowel Disease.
Also, we cover some shocking moral plaigiarism from Feinstein Institute and Dr. Kevin Tracey in managing their public image. We now know that he was not the single pioneer of the transition to Arthritis and IBD trials as the news media claims or potrays him to be. It actually had many people's hand, especially Paul-Peter Tak's.
SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.
Show Credits
Created & Produced by: Arun SridharEditing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam
Social Media:
Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter Feed
You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

What happens in the vagus, stays in vagus?? Not with us at SKRAPS.
“Science Is a Team Sport”
If we truly mean this - I mean, really and truly mean that science is a group effort and not the effort of one person, let’s really dive in to this and embrace our opportunities to set the record straight. And I mean let’s start right now! 
As we endeavor to understand The Wanderer, we must also strive to understand the contributors - and not just the marquee names. We hope to shed light on the nerve, the possibilities, the history, and all of the major players - not just a solo artist. After all, as we near the end of another American football season, I think we can appreciate that Joe Montana was better because of Jerry Rice - Troy Aikman thrived with Michael Irvin, and Tom Brady is the GOAT because of his myriad weapons.
Let’s be true to our intent to make science a team sport and go beyond the lip service.
SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.
Show Credits
Created & Produced by: Arun Sridhar Editing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam
Social Media:
Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter Feed
You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE or you can buy us a coffee - here

Can you tell me the last time that you know of that we eulogised and attributed even the most difficult concepts to a single eureka moment? 
Was it yesterday? 
Was it last week?
Was it last month? 
We have this image of a human jumping out of a bathtub and running naked, shedding your rica or an apple falling from a tree or in the case of psychedelic medicine, the famous bicycle trip of Albert Hoffman.
If you think you love this romanticised version, let me break this idea for you.
Website: www.skrapspodcast.com/season-5
SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.
Show Credits
Created & Produced by: Arun Sridhar Editing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam
Social Media:
Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter Feed
You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

JoJo and Arun are producing some key content that will make you turn your heads in disbelief. Until then, we thought it would be good to get your mind focussed on that wonderful molecule - serotonin that has received fresh life due to its impact on mental health, be it with psychedelics or with electrical stimulation for depression etc.
This episode details some wonderful history of how our body is complicated and yet so wonderful and how there are lessons for everyone irrespective of whether you are a pharmaceutical scientist or a bioelectrician.
SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.
Show Credits
Created & Produced by: Arun Sridhar & JoJo PlattEditing: Arun SridharSound design: Arun Sridhar & Swaminathan ThiruGnanaSambandamSound mixing and mastering: Swaminathan ThiruGnanaSambandam
Social Media:
Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter FeedJoJo's Twitter Feed
You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE

What Is a BCI? And just as importantly, what isn’t a BCI?
This is an unusual episode and an incredibly fun one. Arun and JoJo enlisted some of the field’s top folks to talk through what’s in and what’s out in this exciting field. Amy Kruse is a general partner at Prime Movers Lab and a self-professed Founder turned Funder (and a neuroscientist by training), Matt Angle is the founder and CEO of Paradromics - developing high data rate BCIs, and Marcus Gerhardt is the co-founder and CEO of Blackrock Neurotech and is hoping that their BCIs will disrupt the standard for patient care for the 600 million people that suffer from neurological disorders. 
This episode has it all - technical glitches, laughter, ruffled feathers (Arun’s specialty), and some tantalizing discussions around definitions, dystopia, and delivering on the promise of this incredible technology. 
Arun picks at and Matt defends the valuations of BCI companies - replete with funny characters and great voice acting. Amy chimes in with her point of view (plot twist: she’s on the side of massive market potential) while Marcus makes the claim that BCI companies are, in fact, under valued.
In short, this episode is pretty much your best chance at eavesdropping on a tantalizing conversation among some truly brilliant people on a fascinating topic. 
SKRAPS is your podcast, where we on your behalf explores unsaid, under-appreciated and sometimes, untold stories of sparks of brilliance in science, technology and innovation.
Show Credits
Created & Produced by: Arun Sridhar & JoJo PlattEditing: Arun Sridhar
Social Media:
Twitter: @PodcastSkrapsLinkedIn: SKRAPSArun's Twitter FeedJoJo's Twitter Feed
You can help us fund the production costs by donating as little as $5 or £5 or in any currency of your choice as a one time or a recurring payment HERE